ENSG00000148926


Homo sapiens

Features
Gene ID: ENSG00000148926
  
Biological name :ADM
  
Synonyms : ADM / adrenomedullin / P35318
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 10304680
Gene end: 10307397
  
Corresponding Affymetrix probe sets: 202912_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433062
Ensembl peptide - ENSP00000434354
Ensembl peptide - ENSP00000436837
Ensembl peptide - ENSP00000436607
Ensembl peptide - ENSP00000435124
Ensembl peptide - ENSP00000434749
Ensembl peptide - ENSP00000278175
Ensembl peptide - ENSP00000431438
NCBI entrez gene - 133     See in Manteia.
OMIM - 103275
RefSeq - NM_001124
RefSeq Peptide - NP_001115
swissprot - E9PML4
swissprot - E9PQT2
swissprot - P35318
swissprot - E9PL83
swissprot - E9PQE6
Ensembl - ENSG00000148926
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 admaENSDARG00000015263Danio rerio
 ADMENSGALG00000046593Gallus gallus
 AdmENSMUSG00000030790Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001710  Adrenomedullin
 IPR021116  Calcitonin/adrenomedullin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IDA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0003073 regulation of systemic arterial blood pressure IDA
 biological_processGO:0006171 cAMP biosynthetic process TAS
 biological_processGO:0006701 progesterone biosynthetic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007565 female pregnancy TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010460 positive regulation of heart rate IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IGI
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031102 neuron projection regeneration IEA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035809 regulation of urine volume IDA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045906 negative regulation of vasoconstriction IDA
 biological_processGO:0046879 hormone secretion IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IEA
 biological_processGO:0060712 spongiotrophoblast layer development IEA
 biological_processGO:0097084 vascular smooth muscle cell development IEA
 biological_processGO:0097647 amylin receptor signaling pathway IGI
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1990410 adrenomedullin receptor signaling pathway IDA
 biological_processGO:2001214 positive regulation of vasculogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031700 adrenomedullin receptor binding IDA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122679 RAMP3 / O60896 / receptor activity modifying protein 3  / reaction / complex
 ENSG00000131477 RAMP2 / O60895 / receptor activity modifying protein 2  / complex / reaction
 ENSG00000064989 CALCRL / Q16602 / calcitonin receptor like receptor  / reaction / complex






 

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