ENSG00000131477


Homo sapiens

Features
Gene ID: ENSG00000131477
  
Biological name :RAMP2
  
Synonyms : O60895 / RAMP2 / receptor activity modifying protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.2
Gene start: 42758447
Gene end: 42763041
  
Corresponding Affymetrix probe sets: 205779_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466455
Ensembl peptide - ENSP00000467463
Ensembl peptide - ENSP00000466980
Ensembl peptide - ENSP00000253796
Ensembl peptide - ENSP00000465725
NCBI entrez gene - 10266     See in Manteia.
OMIM - 605154
RefSeq - NM_005854
RefSeq Peptide - NP_005845
swissprot - K7EPN3
swissprot - A0A024R1Z2
swissprot - O60895
swissprot - K7EKQ3
swissprot - K7ENJ8
Ensembl - ENSG00000131477
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ramp2ENSDARG00000037895Danio rerio
 RAMP2ENSGALG00000024449Gallus gallus
 Ramp2ENSMUSG00000001240Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAMP3 / O60896 / receptor activity modifying protein 3ENSG0000012267925
RAMP1 / O60894 / receptor activity modifying protein 1ENSG0000013232923


Protein motifs (from Interpro)
Interpro ID Name
 IPR006985  Receptor activity modifying protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002040 sprouting angiogenesis ISS
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IPI
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008217 regulation of blood pressure ISS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0015031 protein transport IDA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IGI
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034333 adherens junction assembly IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus ISS
 biological_processGO:0043116 negative regulation of vascular permeability IDA
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0070830 bicellular tight junction assembly IDA
 biological_processGO:0070831 basement membrane assembly ISS
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0097084 vascular smooth muscle cell development ISS
 biological_processGO:0097647 amylin receptor signaling pathway IGI
 biological_processGO:1990410 adrenomedullin receptor signaling pathway IPI
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 biological_processGO:2001214 positive regulation of vasculogenesis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:1903143 adrenomedullin receptor complex IDA
 cellular_componentGO:1903440 amylin receptor complex IDA
 molecular_functionGO:0001605 adrenomedullin receptor activity IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0015026 coreceptor activity ISS
 molecular_functionGO:0097643 amylin receptor activity IGI
 molecular_functionGO:1990409 adrenomedullin binding IPI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064989 CALCRL / Q16602 / calcitonin receptor like receptor  / complex
 ENSG00000004948 CALCR / P30988 / calcitonin receptor  / complex
 ENSG00000121351 IAPP / P10997 / islet amyloid polypeptide  / reaction / complex
 ENSG00000148926 ADM / P35318 / adrenomedullin  / complex / reaction
 ENSG00000128165 ADM2 / Q7Z4H4 / adrenomedullin 2  / reaction / complex






 

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