ENSG00000121351


Homo sapiens

Features
Gene ID: ENSG00000121351
  
Biological name :IAPP
  
Synonyms : IAPP / islet amyloid polypeptide / P10997
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p12.1
Gene start: 21354959
Gene end: 21379978
  
Corresponding Affymetrix probe sets: 207062_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000240652
Ensembl peptide - ENSP00000437559
Ensembl peptide - ENSP00000445711
Ensembl peptide - ENSP00000445980
Ensembl peptide - ENSP00000437357
NCBI entrez gene - 3375     See in Manteia.
OMIM - 147940
RefSeq - XM_017019253
RefSeq - NM_000415
RefSeq - NM_001329201
RefSeq Peptide - NP_000406
RefSeq Peptide - NP_001316130
swissprot - A0A024RAU1
swissprot - H0YF85
swissprot - F5H1F0
swissprot - F5H0S1
swissprot - P10997
Ensembl - ENSG00000121351
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017820.1ENSDARG00000105976Danio rerio
 IAPPENSGALG00000013168Gallus gallus
 IappENSMUSG00000041681Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000443  Pro-islet amyloid polypeptide
 IPR001693  Calcitonin peptide-like
 IPR018360  Calcitonin, conserved site
 IPR021116  Calcitonin/adrenomedullin
 IPR021117  Calcitonin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration NAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010739 positive regulation of protein kinase A signaling NAS
 biological_processGO:0010823 negative regulation of mitochondrion organization TAS
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process NAS
 biological_processGO:0032463 negative regulation of protein homooligomerization TAS
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043410 positive regulation of MAPK cascade NAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0051260 protein homooligomerization TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling NAS
 biological_processGO:0097647 amylin receptor signaling pathway ISS
 biological_processGO:1905907 negative regulation of amyloid fibril formation TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0001540 amyloid-beta binding TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of gene expression in beta cells
G alpha (s) signalling events
Calcitonin-like ligand receptors
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122679 RAMP3 / O60896 / receptor activity modifying protein 3  / reaction / complex
 ENSG00000132329 RAMP1 / O60894 / receptor activity modifying protein 1  / reaction / complex
 ENSG00000004948 CALCR / P30988 / calcitonin receptor  / reaction / complex
 ENSG00000131477 RAMP2 / O60895 / receptor activity modifying protein 2  / reaction / complex
 ENSG00000121351 IAPP / P10997 / islet amyloid polypeptide  / -






 

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