ENSMUSG00000041681


Mus musculus

Features
Gene ID: ENSMUSG00000041681
  
Biological name :Iapp
  
Synonyms : Iapp / Islet amyloid polypeptide / P12968
  
Possible biological names infered from orthology : P10997
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G2
Gene start: 142298423
Gene end: 142303961
  
Corresponding Affymetrix probe sets: 10542632 (MoGene1.0st)   1423509_a_at (Mouse Genome 430 2.0 Array)   1423510_at (Mouse Genome 430 2.0 Array)   1437323_a_at (Mouse Genome 430 2.0 Array)   1456004_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043956
NCBI entrez gene - 15874     See in Manteia.
MGI - MGI:96382
RefSeq - NM_010491
RefSeq Peptide - NP_034621
swissprot - P12968
Ensembl - ENSMUSG00000041681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017820.1ENSDARG00000105976Danio rerio
 IAPPENSGALG00000013168Gallus gallus
 IAPPENSG00000121351Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000443  Pro-islet amyloid polypeptide
 IPR001693  Calcitonin peptide-like
 IPR018360  Calcitonin, conserved site
 IPR021116  Calcitonin/adrenomedullin
 IPR021117  Calcitonin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0045596 negative regulation of cell differentiation IMP
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0097647 amylin receptor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cbx2tm1Ykf/Cbx2+
Genetic Background: involves: 129S2/SvPas * C57BL/6NJcl

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Map7mshi/Map7mshi
Genetic Background: BALB/cBy

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041046 Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*  / reaction / complex
 ENSMUSG00000034353 Ramp1 / Q9WTJ5 / receptor (calcitonin) activity modifying protein 1 / O60894* / receptor activity modifying protein 1*  / complex / reaction
 ENSMUSG00000023964 Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*  / complex / reaction
 ENSMUSG00000001240 Ramp2 / Q9WUP0 / Receptor activity-modifying protein 2 / O60895*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr