ENSMUSG00000001240


Mus musculus

Features
Gene ID: ENSMUSG00000001240
  
Biological name :Ramp2
  
Synonyms : Q9WUP0 / Ramp2 / Receptor activity-modifying protein 2
  
Possible biological names infered from orthology : O60895
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 101246028
Gene end: 101259546
  
Corresponding Affymetrix probe sets: 10381298 (MoGene1.0st)   10381304 (MoGene1.0st)   1418187_at (Mouse Genome 430 2.0 Array)   1421051_s_at (Mouse Genome 430 2.0 Array)   1428621_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114061
Ensembl peptide - ENSMUSP00000127718
Ensembl peptide - ENSMUSP00000123150
Ensembl peptide - ENSMUSP00000122072
Ensembl peptide - ENSMUSP00000116331
Ensembl peptide - ENSMUSP00000102903
NCBI entrez gene - 54409     See in Manteia.
MGI - MGI:1859650
RefSeq - NM_019444
RefSeq Peptide - NP_062317
swissprot - A2A4K2
swissprot - F6YPZ1
swissprot - E9Q0S5
swissprot - Q9WUP0
swissprot - D6RHQ4
swissprot - A8XY18
Ensembl - ENSMUSG00000001240
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ramp2ENSDARG00000037895Danio rerio
 RAMP2ENSGALG00000024449Gallus gallus
 RAMP2ENSG00000131477Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*ENSMUSG0000004104623
Ramp1 / Q9WTJ5 / receptor (calcitonin) activity modifying protein 1 / O60894* / receptor activity modifying protein 1*ENSMUSG0000003435321


Protein motifs (from Interpro)
Interpro ID Name
 IPR006985  Receptor activity modifying protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IPI
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0034333 adherens junction assembly IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0070830 bicellular tight junction assembly IEA
 biological_processGO:0070831 basement membrane assembly IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097084 vascular smooth muscle cell development IMP
 biological_processGO:0097647 amylin receptor signaling pathway IEA
 biological_processGO:1990410 adrenomedullin receptor signaling pathway IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 biological_processGO:2001214 positive regulation of vasculogenesis IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:1903143 adrenomedullin receptor complex IEA
 cellular_componentGO:1903440 amylin receptor complex IEA
 molecular_functionGO:0001605 adrenomedullin receptor activity IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0015026 coreceptor activity IDA
 molecular_functionGO:0097643 amylin receptor activity IEA
 molecular_functionGO:1990409 adrenomedullin binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Sox4tm1Vlf/Sox4tm1Vlf,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0003230 abnormal umbilical artery "malformation of the blood vessel of the umbilical cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0003920 abnormal right ventricle morphology "structural anomaly of the right lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0009865 abnormal aorta smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0010664 abnormal vitelline artery morphology "any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Adgrv1tm2Msat/Adgrv1tm2Msat
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ascl2tm1Alj/Ascl2+,Kcnq1ot1tm1.1Mjh/Kcnq1ot1+
Genetic Background: involves: 129 * C57BL/6 * ICR

Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
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Allelic Composition: Ramp2tm1.1Tash/Ramp2tm1.1Tash
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030790 Adm / P97297 / ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide / P35318* / adrenomedullin*  / reaction / complex
 ENSMUSG00000054136 Adm2 / Q7TNK8 / ADM2 Adrenomedullin-2 Intermedin-short / Q7Z4H4* / adrenomedullin 2*  / reaction / complex
 ENSMUSG00000059588 Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*  / complex
 ENSMUSG00000023964 Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*  / complex
 ENSMUSG00000041681 Iapp / P12968 / Islet amyloid polypeptide / P10997*  / reaction / complex






 

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