Manteia - Molecule gene

ENSMUSG00000049796

Mus musculus

Features

Gene ID:	ENSMUSG00000049796

Biological name :	Crh

Synonyms :	Corticoliberin / Crh / Q8CIT0

Possible biological names infered from orthology :	corticotropin releasing hormone / P06850

Species:	Mus musculus

Chr. number:	3
Strand:	-1
Band:	A2
Gene start:	19693401
Gene end:	19695396

Corresponding Affymetrix probe sets:	10497417 (MoGene1.0st) 1457984_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000061185 NCBI entrez gene - 12918 See in Manteia. MGI - MGI:88496 RefSeq - NM_205769 RefSeq Peptide - NP_991338 swissprot - Q8CIT0 Ensembl - ENSMUSG00000049796

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
crha	ENSDARG00000093401	Danio rerio
crhb	ENSDARG00000027657	Danio rerio
CRH	ENSGALG00000037148	Gallus gallus
CRH	ENSG00000147571	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000187	Corticotropin-releasing factor
IPR003620	Urocortin/corticotropin-releasing factor
IPR018446	Corticotropin-releasing factor conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001934	positive regulation of protein phosphorylation	IEA
biological_process	GO:0001963	synaptic transmission, dopaminergic	IEA
biological_process	GO:0003085	negative regulation of systemic arterial blood pressure	IEA
biological_process	GO:0006704	glucocorticoid biosynthetic process	IMP
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0007165	signal transduction	IBA
biological_process	GO:0007565	female pregnancy	IEA
biological_process	GO:0007611	learning or memory	IEA
biological_process	GO:0008202	steroid metabolic process	IEA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0008306	associative learning	IEA
biological_process	GO:0008628	hormone-mediated apoptotic signaling pathway	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010629	negative regulation of gene expression	IEA
biological_process	GO:0010700	negative regulation of norepinephrine secretion	IEA
biological_process	GO:0010942	positive regulation of cell death	IEA
biological_process	GO:0014062	regulation of serotonin secretion	IEA
biological_process	GO:0016101	diterpenoid metabolic process	IEA
biological_process	GO:0021854	hypothalamus development	IEA
biological_process	GO:0030324	lung development	IMP
biological_process	GO:0030325	adrenal gland development	IMP
biological_process	GO:0032811	negative regulation of epinephrine secretion	IEA
biological_process	GO:0033685	negative regulation of luteinizing hormone secretion	IEA
biological_process	GO:0035641	locomotory exploration behavior	IGI
biological_process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
biological_process	GO:0035902	response to immobilization stress	IEA
biological_process	GO:0042220	response to cocaine	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043627	response to estrogen	IEA
biological_process	GO:0043950	positive regulation of cAMP-mediated signaling	IEA
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0045472	response to ether	IEA
biological_process	GO:0048265	response to pain	IEA
biological_process	GO:0050801	ion homeostasis	IEA
biological_process	GO:0051412	response to corticosterone	IEA
biological_process	GO:0051461	positive regulation of corticotropin secretion	IEA
biological_process	GO:0051464	positive regulation of cortisol secretion	IEA
biological_process	GO:0060291	long-term synaptic potentiation	IEA
biological_process	GO:0060456	positive regulation of digestive system process	IEA
biological_process	GO:0060548	negative regulation of cell death	IEA
biological_process	GO:0070093	negative regulation of glucagon secretion	IEA
biological_process	GO:0071314	cellular response to cocaine	IEA
biological_process	GO:0071549	cellular response to dexamethasone stimulus	IEA
biological_process	GO:0090280	positive regulation of calcium ion import	IEA
biological_process	GO:2000310	regulation of NMDA receptor activity	IEA
biological_process	GO:2000854	positive regulation of corticosterone secretion	IEA
biological_process	GO:2000987	positive regulation of behavioral fear response	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043196	varicosity	IEA
cellular_component	GO:0043204	perikaryon	IEA
molecular_function	GO:0005179	hormone activity	IEA
molecular_function	GO:0005184	neuropeptide hormone activity	IBA
molecular_function	GO:0017045	corticotropin-releasing hormone activity	IBA
molecular_function	GO:0051430	corticotropin-releasing hormone receptor 1 binding	IEA
molecular_function	GO:0051431	corticotropin-releasing hormone receptor 2 binding	IEA

Pathways (from Reactome)

Pathway description

Class B/2 (Secretin family receptors)

G alpha (s) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000188	abnormal circulating glucose level	"anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000194	hypercalcemia	"abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000589	thin tail	"a tail with a smaller diameter than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0000639	abnormal adrenal gland morphology	"malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001175	abnormal lung morphology	"malformed organ of respiration" [J:35802]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001176	abnormal lung development	"malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001179	thicker alveolar septa		Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001199	thin skin	"reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001239	abnormal granular layer morphology	"structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001240	abnormal cornified layer morphology	"structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001259	abnormal body weight	"anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Crh^{tm1.1(cre)Dolsn}/Crh⁺,Mc4r^tm1Lowl/Mc4r^tm1Lowl Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Crh^{tm1.1(cre)Dolsn}/Crh⁺,Mc4r^tm1Lowl/Mc4r^tm1Lowl,Oxt^{tm1.1(cre)Dolsn}/Oxt⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001362	abnormal anxiety-related response	"altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Ryr1^tm1.1Inp/Ryr1^tm1.1Inp Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0001426	polydipsia	"excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001739	abnormal adrenal secretion	"altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds Allelic Composition: Crh^tm2.2Maj/Crh^tm2.2Maj Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001759	increased urine glucose level	"a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001762	polyuria	"increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001764	abnormal homeostasis	"anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0001845	abnormal inflammatory response	"aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0001876	decreased inflammatory response	"less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: B2m^tm1Jae/B2m^tm1Jae,Cd4^tm3.2Litt/Cd4^tm3.2Litt Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002421	abnormal cell-mediated immunity	"abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv
MP:0002452	abnormal antigen presenting cell physiology	"impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002664	decreased circulating adrenocorticotropin level	"decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj,Tg(Sim1-cre)1Lowl/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0002665	decreased circulating corticosterone level	"less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj,Tg(Sim1-cre)1Lowl/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Crh^tm2.2Maj/Crh^tm2.2Maj Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0002712	increased circulating glucagon level	"greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002905	decreased circulating parathyroid hormone level	"less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0003718	maternal effect	"expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv Allelic Composition: Crh^tm2.2Maj/Crh^tm2.2Maj Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0003963	abnormal corticosterone level	"anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ryr1^tm1.1Inp/Ryr1^tm1.1Inp Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0003966	abnormal adrenocorticotropin level		Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004781	abnormal surfactant composition	"anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004989	decreased osteoblast cell number	"reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0005095	decreased T cell proliferation	"reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005114	premature hair loss	"release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005345	abnormal circulating corticosterone level	"anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005418	abnormal circulating hormone level	"anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005441	hypercalciuria	"excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005568	increased circulating total protein level	"greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0005660	abnormal circulating adrenaline level	"aberrant concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005661	decreased circulating adrenaline level	"less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005663	abnormal circulating noradrenaline level	"aberrant blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005669	increased circulating leptin level	"greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd}/Polr2a^{Tn(pb-CAG-GCaMP5g)Tvrd} Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
MP:0008294	abnormal zona fasciculata morphology	"any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]	Show Allelic Composition: Invs^inv/Invs⁺ Genetic Background: FVB/N-Invs^inv Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008821	increased blood uric acid level	"greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0009115	abnormal fat cell morphology	"any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0009338	increased splenocyte number	"increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0010809	abnormal Clara cell morphology	"any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0010914	abnormal solitary pulmonary neuroendocrine cell morphology	"any structural anomaly of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011147	increased mesenchymal cell proliferation involved in lung development	"increase in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]	Show Allelic Composition: Crh^tm1Maj/Crh^tm1Maj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0011549	increased urine corticosterone level	"an increased amount of corticosterone in the urine compared to the normal state" [MGI:anna]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0011922	abnormal circulating osteocalcin level	"aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0013307	increased adrenal gland weight	"greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla " [MGI:Anna]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0013308	decreased adrenal gland weight	"reduced average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla" [MGI:anna]	Show Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj,Tg(Sim1-cre)1Lowl/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0013366	adrenal gland atrophy	"acquired diminution of the size of the pair of endocrine glands located above the kidney and responsible for steroid hormone secretion from the cortex and neurotransmitter secretion from the medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes " [MGI:Anna]	Show Allelic Composition: Crh^tm2.1Maj/Crh^tm2.1Maj,Tg(Sim1-cre)1Lowl/? Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N Allelic Composition: Crh^tm2.2Maj/Crh^tm2.2Maj Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N
MP:0020040	decreased bone ossification	"decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J
MP:0020137	decreased bone mineralization	"decrease in the rate at which minerals are deposited into bone" []	Show Allelic Composition: Crh^m1H/Crh⁺ Genetic Background: involves: C3H/HeH * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000003476	Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*	/ complex / reaction
ENSMUSG00000021680	Crhbp / Q60571 / Corticotropin-releasing factor-binding protein / P24387* / corticotropin releasing hormone binding protein*	/ complex / reaction
ENSMUSG00000018634	Crhr1 / P35347 / Corticotropin-releasing factor receptor 1 / P34998* / LINC02210-CRHR1* / LINC02210-CRHR1 readthrough* / corticotropin releasing hormone receptor 1*	/ reaction / complex

0 s.

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