ENSMUSG00000021680


Mus musculus

Features
Gene ID: ENSMUSG00000021680
  
Biological name :Crhbp
  
Synonyms : Corticotropin-releasing factor-binding protein / Crhbp / Q60571
  
Possible biological names infered from orthology : corticotropin releasing hormone binding protein / P24387
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 95431371
Gene end: 95444924
  
Corresponding Affymetrix probe sets: 10411215 (MoGene1.0st)   1436127_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152083
Ensembl peptide - ENSMUSP00000042578
NCBI entrez gene - 12919     See in Manteia.
MGI - MGI:88497
RefSeq - NM_198408
RefSeq Peptide - NP_940800
swissprot - A0A217FL62
swissprot - Q3UY07
swissprot - Q60571
Ensembl - ENSMUSG00000021680
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crhbpENSDARG00000024831Danio rerio
 CRHBPENSGALG00000014994Gallus gallus
 CRHBPENSG00000145708Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008435  Corticotropin-releasing factor-binding protein
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001963 synaptic transmission, dopaminergic IDA
 biological_processGO:0002125 maternal aggressive behavior IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0035865 cellular response to potassium ion ISO
 biological_processGO:0035903 cellular response to immobilization stress ISS
 biological_processGO:0042445 hormone metabolic process IDA
 biological_processGO:0045055 regulated exocytosis IEA
 biological_processGO:0048149 behavioral response to ethanol ISS
 biological_processGO:0051459 regulation of corticotropin secretion ISO
 biological_processGO:0051460 negative regulation of corticotropin secretion ISO
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:0071314 cellular response to cocaine ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071391 cellular response to estrogen stimulus ISS
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0080135 regulation of cellular response to stress ISS
 biological_processGO:0097211 cellular response to gonadotropin-releasing hormone IDA
 biological_processGO:1900011 negative regulation of corticotropin-releasing hormone receptor activity ISO
 biological_processGO:2000310 regulation of NMDA receptor activity IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005767 secondary lysosome ISS
 cellular_componentGO:0005771 multivesicular body ISS
 cellular_componentGO:0005874 microtubule ISS
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0031045 dense core granule ISS
 cellular_componentGO:0043196 varicosity ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0043679 axon terminus ISS
 molecular_functionGO:0042277 peptide binding ISS
 molecular_functionGO:0051424 corticotropin-releasing hormone binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Disp1icb/Disp1tm2Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129/Sv * C57BL/6J * SWR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049796 Crh / Q8CIT0 / Corticoliberin / P06850* / corticotropin releasing hormone*  / complex / reaction






 

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