ENSG00000147571


Homo sapiens

Features
Gene ID: ENSG00000147571
  
Biological name :CRH
  
Synonyms : corticotropin releasing hormone / CRH / P06850
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q13.1
Gene start: 66176382
Gene end: 66178725
  
Corresponding Affymetrix probe sets: 205629_s_at (Human Genome U133 Plus 2.0 Array)   205630_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000276571
NCBI entrez gene - 1392     See in Manteia.
OMIM - 122560
RefSeq - XM_017013093
RefSeq - NM_000756
RefSeq - XM_017013090
RefSeq - XM_017013091
RefSeq - XM_017013092
RefSeq Peptide - NP_000747
swissprot - P06850
swissprot - A0A0S2Z478
Ensembl - ENSG00000147571
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crhaENSDARG00000093401Danio rerio
 crhbENSDARG00000027657Danio rerio
 CRHENSGALG00000037148Gallus gallus
 CrhENSMUSG00000049796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000187  Corticotropin-releasing factor
 IPR003620  Urocortin/corticotropin-releasing factor
 IPR018446  Corticotropin-releasing factor conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IDA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0006704 glucocorticoid biosynthetic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007565 female pregnancy TAS
 biological_processGO:0007567 parturition TAS
 biological_processGO:0007611 learning or memory TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0008628 hormone-mediated apoptotic signaling pathway IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness NAS
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014062 regulation of serotonin secretion IEA
 biological_processGO:0016101 diterpenoid metabolic process IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030325 adrenal gland development IEA
 biological_processGO:0032811 negative regulation of epinephrine secretion IBA
 biological_processGO:0033685 negative regulation of luteinizing hormone secretion IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep NAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045472 response to ether IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0050801 ion homeostasis IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IDA
 biological_processGO:0051464 positive regulation of cortisol secretion IDA
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0060456 positive regulation of digestive system process IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070093 negative regulation of glucagon secretion IBA
 biological_processGO:0071314 cellular response to cocaine IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:2000310 regulation of NMDA receptor activity IDA
 biological_processGO:2000854 positive regulation of corticosterone secretion IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity TAS
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017045 corticotropin-releasing hormone activity IBA
 molecular_functionGO:0051430 corticotropin-releasing hormone receptor 1 binding IEA
 molecular_functionGO:0051431 corticotropin-releasing hormone receptor 2 binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120088 CRHR1 / P34998 / corticotropin releasing hormone receptor 1  / complex / reaction
 ENSG00000145708 CRHBP / P24387 / corticotropin releasing hormone binding protein  / reaction / complex
 ENSG00000106113 CRHR2 / Q13324 / corticotropin releasing hormone receptor 2  / complex / reaction






 

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