ENSG00000164162


Homo sapiens

Features
Gene ID: ENSG00000164162
  
Biological name :ANAPC10
  
Synonyms : ANAPC10 / anaphase promoting complex subunit 10 / Q9UM13
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q31.21
Gene start: 144831908
Gene end: 145098541
  
Corresponding Affymetrix probe sets: 207845_s_at (Human Genome U133 Plus 2.0 Array)   241959_at (Human Genome U133 Plus 2.0 Array)   242777_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423223
Ensembl peptide - ENSP00000423043
Ensembl peptide - ENSP00000423995
Ensembl peptide - ENSP00000493135
Ensembl peptide - ENSP00000478501
Ensembl peptide - ENSP00000425459
Ensembl peptide - ENSP00000424463
Ensembl peptide - ENSP00000310071
Ensembl peptide - ENSP00000403891
Ensembl peptide - ENSP00000421609
NCBI entrez gene - 10393     See in Manteia.
OMIM - 613745
RefSeq - XM_017007644
RefSeq - NM_014885
RefSeq - XM_011531524
RefSeq - XM_011531525
RefSeq - XM_011531526
RefSeq - XM_011531527
RefSeq - XM_011531529
RefSeq - XM_011531530
RefSeq - XM_011531531
RefSeq - XM_011531532
RefSeq - XM_017007638
RefSeq - XM_017007639
RefSeq - XM_017007640
RefSeq - XM_017007641
RefSeq - XM_017007642
RefSeq - XM_017007643
RefSeq - NM_001256706
RefSeq - NM_001256707
RefSeq - NM_001256708
RefSeq - NM_001256709
RefSeq - NM_001256710
RefSeq - NM_001256711
RefSeq - NM_001256712
RefSeq - NM_001318367
RefSeq Peptide - NP_001243636
RefSeq Peptide - NP_001243639
RefSeq Peptide - NP_001243640
RefSeq Peptide - NP_001243641
RefSeq Peptide - NP_001305296
RefSeq Peptide - NP_055700
RefSeq Peptide - NP_001243635
RefSeq Peptide - NP_001243637
RefSeq Peptide - NP_001243638
swissprot - D6RB36
swissprot - D6RA92
swissprot - D6R9Q5
swissprot - D6RD74
swissprot - Q9UM13
swissprot - A0A286YEY6
Ensembl - ENSG00000164162
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anapc10ENSDARG00000090152Danio rerio
 ANAPC10ENSGALG00000028643Gallus gallus
 Q8K2H6ENSMUSG00000036977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004939  APC10/DOC domain
 IPR008979  Galactose-binding-like domain superfamily
 IPR016901  Anaphase-promoting complex subunit APC10/Doc1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process IBA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0051439 obsolete regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 biological_processGO:1904668 positive regulation of ubiquitin protein ligase activity IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005680 anaphase-promoting complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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