ENSG00000164850


Homo sapiens

Features
Gene ID: ENSG00000164850
  
Biological name :GPER1
  
Synonyms : GPER1 / G protein-coupled estrogen receptor 1 / Q99527
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p22.3
Gene start: 1082208
Gene end: 1093815
  
Corresponding Affymetrix probe sets: 210640_s_at (Human Genome U133 Plus 2.0 Array)   211829_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000380277
Ensembl peptide - ENSP00000483756
Ensembl peptide - ENSP00000479553
Ensembl peptide - ENSP00000410487
Ensembl peptide - ENSP00000385151
Ensembl peptide - ENSP00000380281
Ensembl peptide - ENSP00000297469
NCBI entrez gene - 2852     See in Manteia.
OMIM - 601805
RefSeq - NM_001039966
RefSeq - NM_001098201
RefSeq - NM_001505
RefSeq Peptide - NP_001496
RefSeq Peptide - NP_001035055
RefSeq Peptide - NP_001091671
swissprot - Q99527
swissprot - A0A087X0Z4
swissprot - A0A087WVN0
swissprot - A0A024R849
swissprot - C9J3W2
Ensembl - ENSG00000164850
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gper1ENSDARG00000074661Danio rerio
 GPER1ENSGALG00000004064Gallus gallus
 Gper1ENSMUSG00000053647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR146 / Q96CH1 / G protein-coupled receptor 146ENSG0000016484913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001956 positive regulation of neurotransmitter secretion ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002695 negative regulation of leukocyte activation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010948 negative regulation of cell cycle process IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0019228 neuronal action potential ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030263 apoptotic chromosome condensation ISS
 biological_processGO:0030264 nuclear fragmentation involved in apoptotic nuclear change ISS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IDA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IDA
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion ISS
 biological_processGO:0032962 positive regulation of inositol trisphosphate biosynthetic process IDA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IDA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IDA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0050769 positive regulation of neurogenesis ISS
 biological_processGO:0051053 negative regulation of DNA metabolic process ISS
 biological_processGO:0051055 negative regulation of lipid biosynthetic process ISS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IDA
 biological_processGO:0071157 negative regulation of cell cycle arrest ISS
 biological_processGO:0071333 cellular response to glucose stimulus ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IDA
 biological_processGO:0071389 cellular response to mineralocorticoid stimulus ISS
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:0097755 positive regulation of blood vessel diameter ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IDA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISS
 biological_processGO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane ISS
 cellular_componentGO:0032591 dendritic spine membrane ISS
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043198 dendritic shaft ISS
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0044327 dendritic spine head ISS
 cellular_componentGO:0045095 keratin filament IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0048786 presynaptic active zone ISS
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005496 steroid binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017082 mineralocorticoid receptor activity ISS
 molecular_functionGO:0030284 estrogen receptor activity IDA
 molecular_functionGO:1990239 steroid hormone binding IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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