ENSMUSG00000053647


Mus musculus

Features
Gene ID: ENSMUSG00000053647
  
Biological name :Gper1
  
Synonyms : Gper1 / G protein-coupled estrogen receptor 1 / Q8BMP4
  
Possible biological names infered from orthology : Q99527
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 139423151
Gene end: 139427800
  
Corresponding Affymetrix probe sets: 10526952 (MoGene1.0st)   1428250_at (Mouse Genome 430 2.0 Array)   1447583_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080370
NCBI entrez gene - 76854     See in Manteia.
MGI - MGI:1924104
RefSeq - NM_029771
RefSeq - XM_006504757
RefSeq Peptide - NP_084047
swissprot - Q8BMP4
Ensembl - ENSMUSG00000053647
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gper1ENSDARG00000074661Danio rerio
 GPER1ENSGALG00000004064Gallus gallus
 GPER1ENSG00000164850Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr146 / Q99LE2 / G protein-coupled receptor 146 / Q96CH1*ENSMUSG0000004419711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001956 positive regulation of neurotransmitter secretion ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002695 negative regulation of leukocyte activation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010948 negative regulation of cell cycle process IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0019228 neuronal action potential ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030263 apoptotic chromosome condensation ISS
 biological_processGO:0030264 nuclear fragmentation involved in apoptotic nuclear change ISS
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IEA
 biological_processGO:0031959 mineralocorticoid receptor signaling pathway IEA
 biological_processGO:0032024 positive regulation of insulin secretion IDA
 biological_processGO:0032962 positive regulation of inositol trisphosphate biosynthetic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
 biological_processGO:0043401 steroid hormone mediated signaling pathway IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IDA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0050769 positive regulation of neurogenesis IDA
 biological_processGO:0051053 negative regulation of DNA metabolic process ISS
 biological_processGO:0051055 negative regulation of lipid biosynthetic process IDA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070474 positive regulation of uterine smooth muscle contraction IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IDA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0071389 cellular response to mineralocorticoid stimulus ISS
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria ISS
 biological_processGO:0097755 positive regulation of blood vessel diameter ISS
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISS
 biological_processGO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0014069 postsynaptic density ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane ISS
 cellular_componentGO:0032591 dendritic spine membrane ISS
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043198 dendritic shaft ISS
 cellular_componentGO:0043679 axon terminus ISS
 cellular_componentGO:0044327 dendritic spine head ISS
 cellular_componentGO:0045095 keratin filament IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:0048786 presynaptic active zone ISS
 cellular_componentGO:0055037 recycling endosome ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0017082 mineralocorticoid receptor activity ISS
 molecular_functionGO:0030284 estrogen receptor activity IEA
 molecular_functionGO:1990239 steroid hormone binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0002711 decreased glucagon secretion "less than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Sjk/Bax+
Genetic Background: involves: 129X1/SvJ

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Gper1tm1.1Lmlf/Gper1tm1.1Lmlf
Genetic Background: B6.129-Gper1tm1.1Lmlf

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gper1tm1.1Lmlf/Gper1tm1.1Lmlf
Genetic Background: B6.129-Gper1tm1.1Lmlf

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gper1tm1.1Lmlf/Gper1tm1.1Lmlf
Genetic Background: B6.129-Gper1tm1.1Lmlf

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm3Gsc/Creb1tm3Gsc,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0006135 arterial stenosis "abnormal narrowing of the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk2ap1tm1Dtw/Cdk2ap1+
Genetic Background: involves: 129S4/SvJae

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm3Gsc/Creb1tm3Gsc,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf1tm1Gsc/Atf1tm1Gsc,Creb1tm3Gsc/Creb1tm3Gsc,Tg(Dbh-icre)1Gsc/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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