ENSG00000164932


Homo sapiens

Features
Gene ID: ENSG00000164932
  
Biological name :CTHRC1
  
Synonyms : collagen triple helix repeat containing 1 / CTHRC1 / Q96CG8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q22.3
Gene start: 103371515
Gene end: 103382997
  
Corresponding Affymetrix probe sets: 225681_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000330523
Ensembl peptide - ENSP00000430550
Ensembl peptide - ENSP00000430399
Ensembl peptide - ENSP00000416045
NCBI entrez gene - 115908     See in Manteia.
OMIM - 610635
RefSeq - XM_011516824
RefSeq - NM_001256099
RefSeq - NM_138455
RefSeq Peptide - NP_001243028
RefSeq Peptide - NP_612464
swissprot - E7EVQ5
swissprot - E5RK99
swissprot - Q96CG8
Ensembl - ENSG00000164932
  
Related genetic diseases (OMIM): 614266 - Barrett esophagus/esophageal adenocarcinoma, 614266
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cthrc1aENSDARG00000087198Danio rerio
 cthrc1bENSDARG00000001971Danio rerio
 CTHRC1ENSGALG00000033351Gallus gallus
 Cthrc1ENSMUSG00000054196Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008160  Collagen triple helix repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0043932 ossification involved in bone remodeling IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090103 cochlea morphogenesis IEA
 biological_processGO:0090177 establishment of planar polarity involved in neural tube closure IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
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 HP:0011459 Esophageal carcinoma "The presence of a `carcinoma` (MPATH:549) of the `esophagus` (FMA:7131)." [DDD:hfirth]
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 HP:0100580 Barrett esophagus "An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system." [HPO:sdoelken]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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