ENSMUSG00000054196


Mus musculus

Features
Gene ID: ENSMUSG00000054196
  
Biological name :Cthrc1
  
Synonyms : Collagen triple helix repeat-containing protein 1 / Cthrc1 / Q9D1D6
  
Possible biological names infered from orthology : collagen triple helix repeat containing 1 / Q96CG8
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 39076932
Gene end: 39087121
  
Corresponding Affymetrix probe sets: 10423836 (MoGene1.0st)   1452968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070018
Ensembl peptide - ENSMUSP00000153886
Ensembl peptide - ENSMUSP00000154739
NCBI entrez gene - 68588     See in Manteia.
MGI - MGI:1915838
RefSeq - NM_026778
RefSeq - XM_006521318
RefSeq Peptide - NP_081054
swissprot - Q9D1D6
Ensembl - ENSMUSG00000054196
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cthrc1aENSDARG00000087198Danio rerio
 cthrc1bENSDARG00000001971Danio rerio
 CTHRC1ENSGALG00000033351Gallus gallus
 CTHRC1ENSG00000164932Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008160  Collagen triple helix repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IMP
 biological_processGO:0043932 ossification involved in bone remodeling IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090103 cochlea morphogenesis IGI
 biological_processGO:0090177 establishment of planar polarity involved in neural tube closure IGI
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017147 Wnt-protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighmtm1Msn/Ighmtm1Msn
Genetic Background: involves: 129S/SvEv

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cthrc1tm1Hssk/Cthrc1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Ovol1tm1Efu/Ovol1+
Genetic Background: B6.129-Ovol1tm1Efu

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0004393 abnormal cochlear inner hair cell morphology "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cthrc1tm1Hssk/Cthrc1+,Vangl2Lp/Vangl2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trpv4tm1.1Ldtk/Trpv4tm1.1Ldtk,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: C57BL/6 * CD-1 * SJL

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenoptm3.1Rfb/Selenoptm3.1Rfb,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

Allelic Composition: Cthrc1tm1.2Suna/Cthrc1tm1.2Suna
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6NTac * DBA

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0010924 abnormal osteoid morphology "any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
Show

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Cthrc1tm1.1Suna/Cthrc1tm1.1Suna,Ctsktm1(cre)Ska/Ctsk+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrlj * C57BL/6NTac * CBA/JNCrlj

 MP:0030439 decreased osteoblast proliferation "reduction in the expansion rate of osteoblasts by cell division; osteoblasts are skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell" [MGI:anna]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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