ENSG00000165891


Homo sapiens

Features
Gene ID: ENSG00000165891
  
Biological name :E2F7
  
Synonyms : E2F7 / E2F transcription factor 7 / Q96AV8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q21.2
Gene start: 77021247
Gene end: 77065580
  
Corresponding Affymetrix probe sets: 228033_at (Human Genome U133 Plus 2.0 Array)   241725_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449284
Ensembl peptide - ENSP00000448245
Ensembl peptide - ENSP00000449033
Ensembl peptide - ENSP00000323246
Ensembl peptide - ENSP00000393639
Ensembl peptide - ENSP00000447963
NCBI entrez gene - 144455     See in Manteia.
OMIM - 612046
RefSeq - XM_011537969
RefSeq - NM_203394
RefSeq - XM_011537966
RefSeq Peptide - NP_976328
swissprot - H0YIF4
swissprot - F8VSE7
swissprot - Q96AV8
swissprot - F8VXV5
swissprot - H0YHW2
Ensembl - ENSG00000165891
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f7ENSDARG00000008986Danio rerio
 E2F7ENSGALG00000031340Gallus gallus
 E2f7ENSMUSG00000020185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F8 / A0AVK6 / E2F transcription factor 8ENSG0000012917333


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001890 placenta development ISS
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IDA
 biological_processGO:0032466 negative regulation of cytokinesis ISS
 biological_processGO:0032877 positive regulation of DNA endoreduplication ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060707 trophoblast giant cell differentiation ISS
 biological_processGO:0060718 chorionic trophoblast cell differentiation ISS
 biological_processGO:0070365 hepatocyte differentiation ISS
 biological_processGO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle IDA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129173 E2F8 / A0AVK6 / E2F transcription factor 8  / complex / reaction
 ENSG00000165891 E2F7 / Q96AV8 / E2F transcription factor 7  / reaction / complex






 

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