ENSG00000129173


Homo sapiens

Features
Gene ID: ENSG00000129173
  
Biological name :E2F8
  
Synonyms : A0AVK6 / E2F8 / E2F transcription factor 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.1
Gene start: 19224063
Gene end: 19241620
  
Corresponding Affymetrix probe sets: 219990_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000434199
Ensembl peptide - ENSP00000481103
Ensembl peptide - ENSP00000437326
Ensembl peptide - ENSP00000250024
NCBI entrez gene - 79733     See in Manteia.
OMIM - 612047
RefSeq - XM_011520367
RefSeq - NM_001256371
RefSeq - NM_001256372
RefSeq - NM_024680
RefSeq Peptide - NP_001243300
RefSeq Peptide - NP_001243301
RefSeq Peptide - NP_078956
swissprot - E9PMT9
swissprot - A0AVK6
Ensembl - ENSG00000129173
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f8ENSDARG00000057323Danio rerio
 E2F8ENSGALG00000041299Gallus gallus
 E2f8ENSMUSG00000046179Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2F7 / Q96AV8 / E2F transcription factor 7ENSG0000016589134


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0032466 negative regulation of cytokinesis IEA
 biological_processGO:0032877 positive regulation of DNA endoreduplication IEA
 biological_processGO:0033301 cell cycle comprising mitosis without cytokinesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060707 trophoblast giant cell differentiation IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165891 E2F7 / Q96AV8 / E2F transcription factor 7  / complex / reaction
 ENSG00000129173 E2F8 / A0AVK6 / E2F transcription factor 8  / reaction / complex






 

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