ENSMUSG00000046179


Mus musculus

Features
Gene ID: ENSMUSG00000046179
  
Biological name :E2f8
  
Synonyms : E2f8 / Q58FA4 / Transcription factor E2F8
  
Possible biological names infered from orthology : A0AVK6 / E2F transcription factor 8
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B4
Gene start: 48866429
Gene end: 48881596
  
Corresponding Affymetrix probe sets: 10563780 (MoGene1.0st)   1436186_at (Mouse Genome 430 2.0 Array)   1444319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056778
Ensembl peptide - ENSMUSP00000112883
NCBI entrez gene - 108961     See in Manteia.
MGI - MGI:1922038
RefSeq - XM_006540554
RefSeq - NM_001013368
RefSeq - XM_006540553
RefSeq Peptide - NP_001013386
swissprot - Q58FA4
Ensembl - ENSMUSG00000046179
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 e2f8ENSDARG00000057323Danio rerio
 E2F8ENSGALG00000041299Gallus gallus
 E2F8ENSG00000129173Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E2f7 / Q6S7F2 / Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA. / Q96AV8* / E2F transcription factor 7*ENSMUSG0000002018534


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR015633  E2F Family
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0002040 sprouting angiogenesis ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0032466 negative regulation of cytokinesis IMP
 biological_processGO:0032877 positive regulation of DNA endoreduplication IMP
 biological_processGO:0033301 cell cycle comprising mitosis without cytokinesis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060707 trophoblast giant cell differentiation IMP
 biological_processGO:0060718 chorionic trophoblast cell differentiation IMP
 biological_processGO:0070365 hepatocyte differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001047 core promoter binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trp63tm1Aam/Trp63+
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001711 abnormal placenta 
Show

Allelic Composition: E2f7tm1.1Gle/E2f7tm1.1Gle,E2f8tm1.1Gle/E2f8tm1.1Gle
Genetic Background: involves: 129S6/SvEvTac

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Cyp19a1-cre)5912Gle/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp63tm1Aam/Trp63+
Genetic Background: Not Specified

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f7tm1.1Gle/E2f7tm1.1Gle,E2f8tm1.1Gle/E2f8tm1.1Gle
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002132 abnormal respiratory system morphology "anomalous structure of pulmonary tissues " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Cyp19a1-cre)5912Gle/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: E2f7tm1.1Gle/E2f7+,E2f8tm1.1Gle/E2f8tm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Prl2c2tm1(cre)Gle/Prl2c2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Prl3d1tm1(cre)Gle/Prl3d1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Cyp19a1-cre)5912Gle/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008402 increased cellular sensitivity to alkylating agents "greater incidence of cell death following exposure to agents that cause DNA damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1.1Gle/E2f7+,E2f8tm1.1Gle/E2f8tm1.1Gle
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0009658 increased placenta apoptosis "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: E2f7tm1.1Gle/E2f7tm1.1Gle,E2f8tm1.1Gle/E2f8tm1.1Gle
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Tg(Cyp19a1-cre)5912Gle/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Fxntm1Mkn/Fxntm1Mkn,Tg(FXN)YG8Pook/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046179 E2f8 / Q58FA4 / Transcription factor E2F8 / A0AVK6* / E2F transcription factor 8*  / reaction / complex
 ENSMUSG00000020185 E2f7 / Q6S7F2 / Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA. / Q96AV8* / E2F transcription factor 7*  / complex / reaction






 

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