ENSDARG00000057323


Danio rerio

Features
Gene ID: ENSDARG00000057323
  
Biological name :e2f8
  
Synonyms : e2f8 / E2F transcription factor 8 / F1QZ88
  
Possible biological names infered from orthology : A0AVK6 / Q58FA4 / Transcription factor E2F8
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 16576246
Gene end: 16598212
  
Corresponding Affymetrix probe sets: Dr.21415.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000112554
Ensembl peptide - ENSDARP00000105923
Ensembl peptide - ENSDARP00000116062
Ensembl peptide - ENSDARP00000118012
NCBI entrez gene - 565952     See in Manteia.
RefSeq - NM_001347691
RefSeq Peptide - NP_001334620
swissprot - F1QC93
swissprot - E9QE44
swissprot - F1QZ88
swissprot - F1R6D8
ZFIN ID - ZDB-GENE-041111-260
Ensembl - ENSDARG00000057323
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E2F8ENSGALG00000041299Gallus gallus
 E2F8ENSG00000129173Homo sapiens
 E2f8ENSMUSG00000046179Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
e2f7 / Q5RIX9 / E2F transcription factor 7 / Q96AV8* / Q6S7F2* / Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA.*ENSDARG0000000898624


Protein motifs (from Interpro)
Interpro ID Name
 IPR003316  E2F/DP family, winged-helix DNA-binding domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015633  E2F Family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001946 lymphangiogenesis IGI
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008045 motor neuron axon guidance IGI
 biological_processGO:0032466 negative regulation of cytokinesis ISS
 biological_processGO:0032877 positive regulation of DNA endoreduplication ISS
 biological_processGO:0033301 cell cycle comprising mitosis without cytokinesis ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060718 chorionic trophoblast cell differentiation ISS
 biological_processGO:0070365 hepatocyte differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
Show

 ZFA:0000107 eye eye anatomical region hemorrhagic , abnormal
eye blood vessel malformed , abnormal
Show

 ZFA:0000152 retina retina increased amount , abnormal
Show

 ZFA:0001057 intersegmental vein intersegmental vein decreased amount , abnormal
intersegmental vein angiogenic sprout decreased amount , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery malformed , abnormal
intersegmental artery branching involved in blood vessel morphogenesis decreased process quality , abnormal
intersegmental artery decreased amount , abnormal
intersegmental artery broken , abnormal
Show

 ZFA:0001094 whole organism whole organism increased weight , abnormal
Show

 ZFA:0001114 head head increased amount , abnormal
head hemorrhagic , abnormal
head blood vessel malformed , abnormal
Show

 ZFA:0001115 trunk trunk motor neuron increased amount , abnormal
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 ZFA:0001202 optic cup optic cup increased amount , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel increased branchiness , abnormal
intersegmental vessel decreased amount , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel hypoplastic , abnormal
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct morphology , abnormal
thoracic duct lymphangiogenesis disrupted , abnormal
Show

 ZFA:0005604 angiogenic sprout angiogenic sprout physical object quality , abnormal
Show

 ZFA:0005605 lymphangioblast cord lymphangioblast cord lymphangioblast decreased amount , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon guidance decreased process quality , abnormal
motor neuron axon truncated , abnormal
motor neuron axon guidance decreased process quality , ameliorated
motor neuron axon truncated , ameliorated
Show

 ZFA:0009393 lymphangioblast lymphangioblast decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000057323 e2f8 / F1QZ88 / E2F transcription factor 8 / A0AVK6* / Q58FA4* / Transcription factor E2F8 *  / reaction / complex
 ENSDARG00000008986 e2f7 / Q5RIX9 / E2F transcription factor 7 / Q96AV8* / Q6S7F2* / Mus musculus E2F transcription factor 7 (E2f7), transcript variant 2, mRNA.*  / reaction / complex






 

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