ENSG00000166200


Homo sapiens

Features
Gene ID: ENSG00000166200
  
Biological name :COPS2
  
Synonyms : COP9 signalosome subunit 2 / COPS2 / P61201
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q21.1
Gene start: 49106068
Gene end: 49155661
  
Corresponding Affymetrix probe sets: 202467_s_at (Human Genome U133 Plus 2.0 Array)   209838_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299259
Ensembl peptide - ENSP00000452944
Ensembl peptide - ENSP00000453546
Ensembl peptide - ENSP00000453412
Ensembl peptide - ENSP00000373553
Ensembl peptide - ENSP00000443664
NCBI entrez gene - 9318     See in Manteia.
OMIM - 604508
RefSeq - NM_004236
RefSeq - NM_001143887
RefSeq Peptide - NP_001137359
RefSeq Peptide - NP_004227
swissprot - B4DIH5
swissprot - P61201
swissprot - H0YKU5
swissprot - H0YM03
swissprot - H0YMC2
Ensembl - ENSG00000166200
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops2ENSDARG00000004785Danio rerio
 COPS2ENSGALG00000000404Gallus gallus
 Cops2ENSMUSG00000027206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00231 / PSMD11 / proteasome 26S subunit, non-ATPase 11ENSG0000010867122


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000338 protein deneddylation IDA
 biological_processGO:0000715 nucleotide-excision repair, DNA damage recognition TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008180 COP9 signalosome IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity NAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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