ENSMUSG00000027206


Mus musculus

Features
Gene ID: ENSMUSG00000027206
  
Biological name :Cops2
  
Synonyms : COP9 signalosome complex subunit 2 / Cops2 / P61202
  
Possible biological names infered from orthology : COP9 signalosome subunit 2 / P61201
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 125830304
Gene end: 125859139
  
Corresponding Affymetrix probe sets: 10487175 (MoGene1.0st)   1423459_at (Mouse Genome 430 2.0 Array)   1437039_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028635
Ensembl peptide - ENSMUSP00000106089
Ensembl peptide - ENSMUSP00000106090
NCBI entrez gene - 12848     See in Manteia.
MGI - MGI:1330276
RefSeq - NM_001285513
RefSeq - NM_001285507
RefSeq - NM_001285512
RefSeq - NM_009939
RefSeq Peptide - NP_001272442
RefSeq Peptide - NP_001272436
RefSeq Peptide - NP_001272441
RefSeq Peptide - NP_034069
swissprot - A2AQE4
swissprot - P61202
swissprot - Q3V3N6
Ensembl - ENSMUSG00000027206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cops2ENSDARG00000004785Danio rerio
 COPS2ENSGALG00000000404Gallus gallus
 COPS2ENSG00000166200Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psmd11 / Q8BG32 / 26S proteasome non-ATPase regulatory subunit 11 / O00231* / proteasome 26S subunit, non-ATPase 11*ENSMUSG0000001742822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000338 protein deneddylation IBA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0022008 neurogenesis IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0008180 COP9 signalosome ISS
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Cops3tm2Jrl/Cops3tm2Jrl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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