ENSG00000166224


Homo sapiens

Features
Gene ID: ENSG00000166224
  
Biological name :SGPL1
  
Synonyms : O95470 / SGPL1 / sphingosine-1-phosphate lyase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q22.1
Gene start: 70815961
Gene end: 70881173
  
Corresponding Affymetrix probe sets: 208381_s_at (Human Genome U133 Plus 2.0 Array)   212321_at (Human Genome U133 Plus 2.0 Array)   212322_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000299297
Ensembl peptide - ENSP00000362298
Ensembl peptide - ENSP00000386549
NCBI entrez gene - 8879     See in Manteia.
OMIM - 603729
RefSeq - XM_011540318
RefSeq - XM_005270263
RefSeq - XM_006718053
RefSeq - XM_011540316
RefSeq - XM_011540317
RefSeq - NM_003901
RefSeq Peptide - NP_003892
swissprot - H7BXL7
swissprot - H0Y3V8
swissprot - O95470
Ensembl - ENSG00000166224
  
Related genetic diseases (OMIM): 617575 - Nephrotic syndrome 14, 617575
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgpl1ENSDARG00000061375Danio rerio
 SGPL1ENSGALG00000004553Gallus gallus
 Sgpl1ENSMUSG00000020097Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002129  Pyridoxal phosphate-dependent decarboxylase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001553 luteinization IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IDA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0006672 ceramide metabolic process IDA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008210 estrogen metabolic process IEA
 biological_processGO:0008585 female gonad development IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0010761 fibroblast migration IEA
 biological_processGO:0019752 carboxylic acid metabolic process IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0030149 sphingolipid catabolic process NAS
 biological_processGO:0033327 Leydig cell differentiation IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048705 skeletal system morphogenesis IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060325 face morphogenesis IEA
 biological_processGO:0097190 apoptotic signaling pathway IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane NAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008117 sphinganine-1-phosphate aldolase activity TAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016831 carboxy-lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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