Manteia - Molecule gene

ENSMUSG00000020097

Mus musculus

Features

Gene ID:	ENSMUSG00000020097

Biological name :	Sgpl1

Synonyms :	Q8R0X7 / Sgpl1 / Sphingosine-1-phosphate lyase 1

Possible biological names infered from orthology :	O95470

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	B4
Gene start:	61098642
Gene end:	61147703

Corresponding Affymetrix probe sets:	10369413 (MoGene1.0st) 1415892_at (Mouse Genome 430 2.0 Array) 1415893_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000112975 Ensembl peptide - ENSMUSP00000119550 Ensembl peptide - ENSMUSP00000117848 Ensembl peptide - ENSMUSP00000115907 Ensembl peptide - ENSMUSP00000115561 Ensembl peptide - ENSMUSP00000090155 NCBI entrez gene - 20397 See in Manteia. MGI - MGI:1261415 RefSeq - XM_017313860 RefSeq - NM_001316673 RefSeq - NM_001316674 RefSeq - NM_009163 RefSeq Peptide - NP_033189 RefSeq Peptide - NP_001303602 RefSeq Peptide - NP_001303603 swissprot - D3YY13 swissprot - D3Z1Z3 swissprot - D3YZT4 swissprot - Q8R0X7 swissprot - D6REF7 Ensembl - ENSMUSG00000020097

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sgpl1	ENSDARG00000061375	Danio rerio
SGPL1	ENSGALG00000004553	Gallus gallus
SGPL1	ENSG00000166224	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR002129	Pyridoxal phosphate-dependent decarboxylase
IPR015421	Pyridoxal phosphate-dependent transferase, major domain
IPR015422	Pyridoxal phosphate-dependent transferase domain 1
IPR015424	Pyridoxal phosphate-dependent transferase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001553	luteinization	IMP
biological_process	GO:0001570	vasculogenesis	IMP
biological_process	GO:0001822	kidney development	IMP
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0006631	fatty acid metabolic process	ISO
biological_process	GO:0006665	sphingolipid metabolic process	IEA
biological_process	GO:0006672	ceramide metabolic process	ISS
biological_process	GO:0006807	nitrogen compound metabolic process	IMP
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0008209	androgen metabolic process	IMP
biological_process	GO:0008210	estrogen metabolic process	IMP
biological_process	GO:0008585	female gonad development	IMP
biological_process	GO:0009791	post-embryonic development	IMP
biological_process	GO:0010761	fibroblast migration	IMP
biological_process	GO:0019752	carboxylic acid metabolic process	IEA
biological_process	GO:0030097	hemopoiesis	IMP
biological_process	GO:0030149	sphingolipid catabolic process	ISO
biological_process	GO:0033327	Leydig cell differentiation	IMP
biological_process	GO:0040014	regulation of multicellular organism growth	IMP
biological_process	GO:0048008	platelet-derived growth factor receptor signaling pathway	IMP
biological_process	GO:0048705	skeletal system morphogenesis	IMP
biological_process	GO:0060021	roof of mouth development	IMP
biological_process	GO:0060325	face morphogenesis	IMP
biological_process	GO:0097190	apoptotic signaling pathway	ISS
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0008117	sphinganine-1-phosphate aldolase activity	ISO
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0016831	carboxy-lyase activity	IEA
molecular_function	GO:0030170	pyridoxal phosphate binding	IEA

Pathways (from Reactome)

Pathway description

Sphingolipid de novo biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000107	abnormal frontal bone morphology	"malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Scrib^{tm1b(NCOM)Mfgc}/Scrib^{tm1b(NCOM)Mfgc} Genetic Background: C57BL/6N-Scrib^{tm1a(NCOM)Mfgc}/Tcp
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000516	abnormal urinary system morphology	"structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000540	abnormal urinary bladder epithelium morphology	"malformation of the epithelial layer of the urinary bladder" [MGI:tc]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Sgpl1^tm1.2Npa/Sgpl1^tm1.2Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0000711	thymic cortex hypoplasia	"reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0000714	increased thymocyte number	"greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0000767	abnormal smooth muscle morphology	"anomalous structure of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001121	uterine hypoplasia	"reduced size of the uterus due to decreased cell number" [J:45065]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001126	abnormal ovary morphology	"malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001127	small ovary	"reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001134	absent corpora lutea	"missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001156	abnormal spermatogenesis	"incomplete maturation or aberrant formation of the male gametes" [J:58959]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001179	thicker alveolar septa		Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001731	abnormal postnatal growth	"anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]	Show Allelic Composition: Sgpl1^tm1.2Npa/Sgpl1^tm1.2Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: F2r^tm1Ajc/F2r^tm1Ajc,F2rl1^tm1Cgh/F2rl1^tm1Cgh Genetic Background: involves: 129S4/SvJae
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0001859	kidney inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001914	hemorrhage	"loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6) Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6) Allelic Composition: Pdgfra^tm1Sor/Pdgfra⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rad50^tm2.1Flv/Rad50^tm2.1Flv Genetic Background: B6.129S6-Rad50^tm2.1Flv Allelic Composition: Sgpl1^tm1.2Npa/Sgpl1^tm1.2Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0002136	abnormal kidney physiology	"altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: F2r^tm1Ajc/F2r^tm1Ajc,F2rl1^tm1Cgh/F2rl1^tm1Cgh Genetic Background: involves: 129S4/SvJae
MP:0002223	lymphoid hypoplasia	"decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002270	abnormal alveoli morphology	"any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002339	abnormal lymph node morphology	"anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	"anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002367	abnormal thymus lobule morphology	"anomalous structure or development of the basic structural unit of the thymus" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002401	abnormal lymphopoiesis	"atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002444	abnormal T cell physiology	"anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: F2r^tm1Ajc/F2r^tm1Ajc,F2rl1^tm1Cgh/F2rl1^tm1Cgh Genetic Background: involves: 129S4/SvJae
MP:0002534	type IV hypersensitivity reaction	"an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0002780	decreased circulating testosterone level	"less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0003091	abnormal cell migration	"defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0003630	abnormal urothelium	"malformation of the mucus lining in organs of the urinary tract, consisting in the bladder of three to seven cell layers" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95622]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0004969	pale kidney	"kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0004972	abnormal regulatory T cell number	"deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor} Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0005097	polychromatophilia	"condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005181	decreased circulating estradiol level	"less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005536	Leydig cell hypoplasia	"reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0005565	increased blood urea nitrogen level	"high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0006379	abnormal spermatocyte morphology	"anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0006380	abnormal spermatid morphology	"anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0006418	abnormal testis cord formation	"any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J
MP:0008082	increased single-positive T cell number	"greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J
MP:0008083	decreased single-positive T cell number	"reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0008101	lymph node hypoplasia	"underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008146	asymmetric rib-sternum attachment	"loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0008174	decreased follicular B cell number	"reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Actb^{tm4(cre/ERT2)Npa}/Actb⁺,Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa Genetic Background: involves: BALB/cJ * C57BL/6
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0008869	anovulation	"complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0009370	decreased thecal cell number	"fewer than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0009887	abnormal palatal shelf fusion at midline	"any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages" [PMID:16942766]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0009895	decreased palatine shelf size	"reduced size of the bony projection of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Rpgrip1l⁺ Genetic Background: C57BL/6N-Rpgrip1l^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0011129	decreased secondary ovarian follicle number	"fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers" [MGI:csmith]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0011385	abnormal testosterone level	"anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females" [ISBN:0-683-40008-8]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0011708	decreased fibroblast cell migration	"reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor
MP:0013591	thymus medulla hyperplasia	"overdevelopment or increased size, usually due to an increased cell number, of the inner area of thymus lobules" [MGI:Anna]	Show Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J
MP:0020550	multinucleated giant male germ cells	"presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]	Show Allelic Composition: Pdgfrb^tm1Sor/Pdgfrb⁺,Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor} Genetic Background: either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)
MP:0030383	small presphenoid bone	"reduced size of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [MGI:anna]	Show Allelic Composition: Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Genetic Background: involves: 129S4/SvJaeSor

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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