ENSG00000167315


Homo sapiens

Features
Gene ID: ENSG00000167315
  
Biological name :ACAA2
  
Synonyms : ACAA2 / acetyl-CoA acyltransferase 2 / P42765
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q21.1
Gene start: 49782167
Gene end: 49813960
  
Corresponding Affymetrix probe sets: 202002_at (Human Genome U133 Plus 2.0 Array)   202003_s_at (Human Genome U133 Plus 2.0 Array)   241114_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466015
Ensembl peptide - ENSP00000468157
Ensembl peptide - ENSP00000466466
Ensembl peptide - ENSP00000285093
Ensembl peptide - ENSP00000465045
Ensembl peptide - ENSP00000465095
NCBI entrez gene - 10449     See in Manteia.
OMIM - 604770
RefSeq - NM_006111
RefSeq Peptide - NP_006102
swissprot - K7EME0
swissprot - K7ER88
swissprot - A0A0B4J2A4
swissprot - P42765
swissprot - K7EJ68
swissprot - K7EJB1
Ensembl - ENSG00000167315
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acaa2ENSDARG00000038881Danio rerio
 ACAA2ENSGALG00000031142Gallus gallus
 Acaa2ENSMUSG00000036880Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACAT2 / Q9BWD1 / acetyl-CoA acetyltransferase 2ENSG0000012043742
ACAT1 / P24752 / acetyl-CoA acetyltransferase 1ENSG0000007523940


Protein motifs (from Interpro)
Interpro ID Name
 IPR002155  Thiolase
 IPR016039  Thiolase-like
 IPR020610  Thiolase, active site
 IPR020613  Thiolase, conserved site
 IPR020615  Thiolase, acyl-enzyme intermediate active site
 IPR020616  Thiolase, N-terminal
 IPR020617  Thiolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IBA
 biological_processGO:0006695 cholesterol biosynthetic process NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003988 acetyl-CoA C-acyltransferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167315 ACAA2 / P42765 / acetyl-CoA acyltransferase 2  / complex






 

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