ENSG00000168710


Homo sapiens

Features
Gene ID: ENSG00000168710
  
Biological name :AHCYL1
  
Synonyms : adenosylhomocysteinase like 1 / AHCYL1 / O43865
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 109984686
Gene end: 110023741
  
Corresponding Affymetrix probe sets: 200848_at (Human Genome U133 Plus 2.0 Array)   200849_s_at (Human Genome U133 Plus 2.0 Array)   200850_s_at (Human Genome U133 Plus 2.0 Array)   207464_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000352092
Ensembl peptide - ENSP00000358814
Ensembl peptide - ENSP00000377238
NCBI entrez gene - 10768     See in Manteia.
OMIM - 607826
RefSeq - NM_006621
RefSeq - XM_011540535
RefSeq - NM_001242673
RefSeq - NM_001242674
RefSeq - NM_001242675
RefSeq - NM_001242676
RefSeq Peptide - NP_001229602
RefSeq Peptide - NP_001229603
RefSeq Peptide - NP_001229604
RefSeq Peptide - NP_001229605
RefSeq Peptide - NP_006612
swissprot - O43865
swissprot - A0A024R0A8
Ensembl - ENSG00000168710
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahcyl1ENSDARG00000056331Danio rerio
 AHCYL1ENSGALG00000000329Gallus gallus
 Ahcyl1ENSMUSG00000027893Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AHCYL2 / Q96HN2 / adenosylhomocysteinase like 2ENSG0000015846786
AHCY / P23526 / adenosylhomocysteinaseENSG0000010144441


Protein motifs (from Interpro)
Interpro ID Name
 IPR000043  Adenosylhomocysteinase-like
 IPR015878  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
 IPR020082  S-adenosyl-L-homocysteine hydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006378 mRNA polyadenylation IDA
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IMP
 biological_processGO:0031440 regulation of mRNA 3"-end processing IDA
 biological_processGO:0032412 regulation of ion transmembrane transporter activity IMP
 biological_processGO:0033353 S-adenosylmethionine cycle IBA
 biological_processGO:0038166 angiotensin-activated signaling pathway IDA
 biological_processGO:0042045 epithelial fluid transport IEA
 biological_processGO:0044070 regulation of anion transport IEA
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004013 adenosylhomocysteinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
PLC beta mediated events
DAG and IP3 signaling
Role of phospholipids in phagocytosis
FCERI mediated Ca+2 mobilization
Regulation of insulin secretion
VEGFR2 mediated cell proliferation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123104 ITPR2 / Q14571 / inositol 1,4,5-trisphosphate receptor type 2  / reaction / complex
 ENSG00000150995 ITPR1 / Q14643 / inositol 1,4,5-trisphosphate receptor type 1  / reaction / complex
 ENSG00000096433 ITPR3 / Q14573 / inositol 1,4,5-trisphosphate receptor type 3  / reaction / complex






 

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contact: otassy@igbmc.fr