ENSMUSG00000027893


Mus musculus

Features
Gene ID: ENSMUSG00000027893
  
Biological name :Ahcyl1
  
Synonyms : Ahcyl1 / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA. / Q80SW1
  
Possible biological names infered from orthology : adenosylhomocysteinase like 1 / O43865
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.3
Gene start: 107663118
Gene end: 107696560
  
Corresponding Affymetrix probe sets: 10501143 (MoGene1.0st)   1425576_at (Mouse Genome 430 2.0 Array)   1426830_a_at (Mouse Genome 430 2.0 Array)   1426831_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029490
Ensembl peptide - ENSMUSP00000117909
Ensembl peptide - ENSMUSP00000121510
NCBI entrez gene - 229709     See in Manteia.
MGI - MGI:2385184
RefSeq - XM_017319558
RefSeq - NM_001357113
RefSeq - NM_145542
RefSeq - XM_006501408
RefSeq - XM_017319556
RefSeq - XM_017319557
RefSeq Peptide - NP_001344042
RefSeq Peptide - NP_663517
swissprot - F7ATQ6
swissprot - Q80SW1
swissprot - D3Z2Q0
Ensembl - ENSMUSG00000027893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahcyl1ENSDARG00000056331Danio rerio
 AHCYL1ENSGALG00000000329Gallus gallus
 AHCYL1ENSG00000168710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ahcyl2 / Q68FL4 / S-adenosylhomocysteine hydrolase-like 2 / Q96HN2* / adenosylhomocysteinase like 2*ENSMUSG0000002977286
Gm4737 / P50247 / predicted gene 4737 / AHCY* / P23526* / adenosylhomocysteinase*ENSMUSG0000004808742
Ahcy / P50247 / Adenosylhomocysteinase / P23526*ENSMUSG0000002759742


Protein motifs (from Interpro)
Interpro ID Name
 IPR000043  Adenosylhomocysteinase-like
 IPR015878  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
 IPR020082  S-adenosyl-L-homocysteine hydrolase, conserved site
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0010765 positive regulation of sodium ion transport IEA
 biological_processGO:0031440 regulation of mRNA 3"-end processing IEA
 biological_processGO:0032412 regulation of ion transmembrane transporter activity IEA
 biological_processGO:0033353 S-adenosylmethionine cycle IBA
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0042045 epithelial fluid transport IDA
 biological_processGO:0044070 regulation of anion transport IGI
 biological_processGO:0051592 response to calcium ion IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004013 adenosylhomocysteinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0010148 abnormal exocrine pancreas physiology "any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes" [MESH:A03.734.540, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wdr13tm1Kuma/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / complex / reaction
 ENSMUSG00000042644 Itpr3 / P70227 / Inositol 1,4,5-trisphosphate receptor type 3 / Q14573*  / complex / reaction
 ENSMUSG00000030287 Itpr2 / Q9Z329 / Inositol 1,4,5-trisphosphate receptor type 2 / Q14571*  / reaction / complex






 

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