ENSMUSG00000027597


Mus musculus

Features
Gene ID: ENSMUSG00000027597
  
Biological name :Ahcy
  
Synonyms : Adenosylhomocysteinase / Ahcy / P50247
  
Possible biological names infered from orthology : P23526
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 155059310
Gene end: 155074497
  
Corresponding Affymetrix probe sets: 10344713 (MoGene1.0st)   10439762 (MoGene1.0st)   10488816 (MoGene1.0st)   1417125_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116774
Ensembl peptide - ENSMUSP00000061851
NCBI entrez gene - 269378     See in Manteia.
MGI - MGI:87968
RefSeq - NM_016661
RefSeq Peptide - NP_057870
swissprot - A2ALT5
swissprot - P50247
swissprot - Q3TF14
Ensembl - ENSMUSG00000027597
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ahcyENSDARG00000005191Danio rerio
 AHCYENSGALG00000033677Gallus gallus
 AHCYENSG00000101444Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm4737 / P50247 / predicted gene 4737 / AHCY* / P23526* / adenosylhomocysteinase*ENSMUSG00000048087100
Ahcyl2 / Q68FL4 / S-adenosylhomocysteine hydrolase-like 2 / Q96HN2* / adenosylhomocysteinase like 2*ENSMUSG0000002977251
Ahcyl1 / Q80SW1 / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA. / O43865* / adenosylhomocysteinase like 1*ENSMUSG0000002789351


Protein motifs (from Interpro)
Interpro ID Name
 IPR000043  Adenosylhomocysteinase-like
 IPR015878  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
 IPR020082  S-adenosyl-L-homocysteine hydrolase, conserved site
 IPR034373  Adenosylhomocysteinase
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0019510 S-adenosylhomocysteine catabolic process IDA
 biological_processGO:0033353 S-adenosylmethionine cycle IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0004013 adenosylhomocysteinase activity IDA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043621 protein self-association IPI
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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