ENSDARG00000005191


Danio rerio

Features
Gene ID: ENSDARG00000005191
  
Biological name :ahcy
  
Synonyms : adenosylhomocysteinase / ahcy
  
Possible biological names infered from orthology : Gm4737 / P23526 / P50247 / predicted gene 4737
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 49926115
Gene end: 49966288
  
Corresponding Affymetrix probe sets: Dr.25468.1.A1_at (Zebrafish Array)   Dr.6924.1.S1_at (Zebrafish Array)   NM_199218_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000002844
NCBI entrez gene - 387530     See in Manteia.
RefSeq - NM_199218
RefSeq Peptide - NP_954688
swissprot - Q803T5
ZFIN ID - ZDB-GENE-031219-6
Ensembl - ENSDARG00000005191
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AHCYENSGALG00000033677Gallus gallus
 AHCYENSG00000101444Homo sapiens
 AhcyENSMUSG00000027597Mus musculus
 Gm4737ENSMUSG00000048087Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ahcyl1 / adenosylhomocysteinase-like 1 / O43865* / Q80SW1* / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA.*ENSDARG0000005633151
ahcyl2 / adenosylhomocysteinase-like 2 / Q68FL4* / Q96HN2* / S-adenosylhomocysteine hydrolase-like 2*ENSDARG0000003934351
zgc:158222 / Q96HN2* / Q68FL4* / AHCYL2* / adenosylhomocysteinase like 2* / S-adenosylhomocysteine hydrolase-like 2*ENSDARG0000005187347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000043  Adenosylhomocysteinase-like
 IPR015878  S-adenosyl-L-homocysteine hydrolase, NAD binding domain
 IPR016040  NAD(P)-binding domain
 IPR020082  S-adenosyl-L-homocysteine hydrolase, conserved site
 IPR034373  Adenosylhomocysteinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0019510 S-adenosylhomocysteine catabolic process IEA
 biological_processGO:0033353 S-adenosylmethionine cycle IMP
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004013 adenosylhomocysteinase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
liver nucleus increased size , abnormal
liver lipid droplet present , abnormal
liver size , ameliorated
liver lipid increased amount , abnormal
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 ZFA:0000208 gall bladder gall bladder decreased functionality , abnormal
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 ZFA:0001249 exocrine pancreas exocrine pancreas quality , abnormal
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 ZFA:0005164 bile ductule bile ductule degenerate , abnormal
bile ductule unlumenized , abnormal
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 ZFA:0005169 intrahepatic bile duct intrahepatic bile duct decreased branchiness , abnormal
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 ZFA:0009091 melanocyte melanocyte quality , abnormal
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 ZFA:0009111 hepatocyte hepatocyte mitochondrion structure , abnormal
hepatocyte mitochondrial crista condensed , abnormal
hepatocyte increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005191 ahcy / adenosylhomocysteinase / Gm4737* / P23526* / P50247* / predicted gene 4737*  / complex






 

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