ENSMUSG00000030287


Mus musculus

Features
Gene ID: ENSMUSG00000030287
  
Biological name :Itpr2
  
Synonyms : Inositol 1,4,5-trisphosphate receptor type 2 / Itpr2 / Q9Z329
  
Possible biological names infered from orthology : Q14571
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G3
Gene start: 146108299
Gene end: 146502223
  
Corresponding Affymetrix probe sets: 10549282 (MoGene1.0st)   1421678_at (Mouse Genome 430 2.0 Array)   1424833_at (Mouse Genome 430 2.0 Array)   1424834_s_at (Mouse Genome 430 2.0 Array)   1427287_s_at (Mouse Genome 430 2.0 Array)   1427693_at (Mouse Genome 430 2.0 Array)   1444418_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078526
Ensembl peptide - ENSMUSP00000144726
Ensembl peptide - ENSMUSP00000121773
Ensembl peptide - ENSMUSP00000119110
Ensembl peptide - ENSMUSP00000049584
NCBI entrez gene - 16439     See in Manteia.
MGI - MGI:99418
RefSeq - XM_017321411
RefSeq - NM_010586
RefSeq - NM_019923
RefSeq - XM_006507026
RefSeq Peptide - NP_034716
RefSeq Peptide - NP_064307
swissprot - B2KF92
swissprot - A0A0N4SUL2
swissprot - B2KF89
swissprot - Q9Z329
Ensembl - ENSMUSG00000030287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO834850.1ENSDARG00000111261Danio rerio
 itpr2ENSDARG00000011909Danio rerio
 ITPR2ENSG00000123104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*ENSMUSG0000003010270
Itpr3 / P70227 / Inositol 1,4,5-trisphosphate receptor type 3 / Q14573*ENSMUSG0000004264464
Ryr1 / E9PZQ0 / Ryanodine receptor 1 / P21817*ENSMUSG0000003059224
Ryr2 / E9Q401 / ryanodine receptor 2, cardiac / Q92736* / ryanodine receptor 2*ENSMUSG0000002131324
Ryr3 / A2AGL3 / Ryanodine receptor 3 / Q15413*ENSMUSG0000005737824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000493  Inositol 1,4,5-trisphosphate receptor
 IPR000699  RIH domain
 IPR005821  Ion transport domain
 IPR011989  Armadillo-like helical
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016024  Armadillo-type fold
 IPR016093  MIR motif
 IPR035910  RyR/IP3 receptor binding core, RIH domain superfamily
 IPR036300  Mir domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071361 cellular response to ethanol IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IDA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015278 calcium-release channel activity IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:0070679 inositol 1,4,5 trisphosphate binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0002694 abnormal pancreas secretion "altered ability of the pancreas to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0005310 abnormal salivary gland physiology "anomalous function of any of the glands in the mouth that secrete saliva" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx8tm1Vpa/Lhx8tm1Vpa
Genetic Background: B6.Cg-Lhx8tm1Vpa

 MP:0013368 abnormal sweat gland physiology "any functional anomaly of the coiled tubular glands of the skin that secrete sweat" [MGI:Anna]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013371 hypohidrosis "decreased sweating in response to appropriate stimuli" [MGI:Anna]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042644 Itpr3 / P70227 / Inositol 1,4,5-trisphosphate receptor type 3 / Q14573*  / complex
 ENSMUSG00000027893 Ahcyl1 / Q80SW1 / Mus musculus S-adenosylhomocysteine hydrolase-like 1 (Ahcyl1), transcript variant 5, mRNA. / O43865* / adenosylhomocysteinase like 1*  / reaction / complex
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / complex
 ENSMUSG00000030987 Stim1 / P70302 / Stromal interaction molecule 1 / Q13586*  / reaction
 ENSMUSG00000030287 Itpr2 / Q9Z329 / Inositol 1,4,5-trisphosphate receptor type 2 / Q14571*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr