ENSMUSG00000030987


Mus musculus

Features
Gene ID: ENSMUSG00000030987
  
Biological name :Stim1
  
Synonyms : P70302 / Stim1 / Stromal interaction molecule 1
  
Possible biological names infered from orthology : Q13586
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 102267806
Gene end: 102437319
  
Corresponding Affymetrix probe sets: 10555681 (MoGene1.0st)   1436945_x_at (Mouse Genome 430 2.0 Array)   1448320_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147410
Ensembl peptide - ENSMUSP00000147443
Ensembl peptide - ENSMUSP00000033289
Ensembl peptide - ENSMUSP00000147314
NCBI entrez gene - 20866     See in Manteia.
MGI - MGI:107476
RefSeq - XM_017322078
RefSeq - XM_006507533
RefSeq - XM_006507534
RefSeq - XM_006507535
RefSeq - XM_006507536
RefSeq - XM_006507537
RefSeq - NM_009287
RefSeq Peptide - NP_033313
swissprot - A0A1B0GRA5
swissprot - A0A1B0GR78
swissprot - A0A1B0GQZ3
swissprot - P70302
Ensembl - ENSMUSG00000030987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stim1aENSDARG00000060723Danio rerio
 stim1bENSDARG00000061560Danio rerio
 STIM1ENSGALG00000041762Gallus gallus
 STIM1ENSG00000167323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stim2 / P83093 / stromal interaction molecule 2 / Q9P246*ENSMUSG0000003915646


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR030463  Stromal interaction molecule 1
 IPR032393  Stromal interaction molecule, Orai1-activating region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002115 store-operated calcium entry IEA
 biological_processGO:0005513 detection of calcium ion ISS
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IMP
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IBA
 biological_processGO:0014902 myotube differentiation IMP
 biological_processGO:0032237 activation of store-operated calcium channel activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0070166 enamel mineralization ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:2001256 regulation of store-operated calcium entry IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032541 cortical endoplasmic reticulum ISO
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane ISS
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015279 store-operated calcium channel activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051010 microtubule plus-end binding ISO


Pathways (from Reactome)
Pathway description
Ion homeostasis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrrk2tm1Mjfa/Lrrk2tm1Mjfa
Genetic Background: involves: C57BL/6

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stim1tm1.1Rao/Stim1tm1.1Rao
Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stim1tm1.1Rao/Stim1tm1.1Rao
Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stim1Gt(GST050)Byg/Stim1Gt(GST050)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008407 decreased cellular sensitivity to hydrogen peroxide "reduced incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Stim1tm1.1Rao/Stim1tm1.1Rao
Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stim1tm1.1Rao/Stim1tm1.1Rao
Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Stim1Gt(RRS558)Byg/Stim1Gt(RRS558)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Tpi1a-m6Neu/Tpi1+
Genetic Background: involves: 101/El * C3H/El

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stim1tm1.1Rao/Stim1tm1.1Rao
Genetic Background: involves: BALB/cJ * C57BL/6 * ICR * SJL

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011747 myelofibrosis "appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias" [ISBN:0-683-40008-8]
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Allelic Composition: Prkntm1Ccs/Prkntm1Ccs,Tg(Th-SNCA*)1.2Ccs/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030102 Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*  / reaction
 ENSMUSG00000030987 Stim1 / P70302 / Stromal interaction molecule 1 / Q13586*  / reaction / complex
 ENSMUSG00000042644 Itpr3 / P70227 / Inositol 1,4,5-trisphosphate receptor type 3 / Q14573*  / reaction
 ENSMUSG00000030287 Itpr2 / Q9Z329 / Inositol 1,4,5-trisphosphate receptor type 2 / Q14571*  / reaction






 

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