ENSMUSG00000039156


Mus musculus

Features
Gene ID: ENSMUSG00000039156
  
Biological name :Stim2
  
Synonyms : P83093 / Stim2 / stromal interaction molecule 2
  
Possible biological names infered from orthology : Q9P246
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C1
Gene start: 53998499
Gene end: 54121057
  
Corresponding Affymetrix probe sets: 10521950 (MoGene1.0st)   1434219_at (Mouse Genome 430 2.0 Array)   1441024_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113174
Ensembl peptide - ENSMUSP00000143855
Ensembl peptide - ENSMUSP00000144078
NCBI entrez gene - 116873     See in Manteia.
MGI - MGI:2151156
RefSeq - XM_006503682
RefSeq - NM_001081103
RefSeq Peptide - NP_001074572
swissprot - F6WBP9
swissprot - A5CVE4
swissprot - P83093
swissprot - I1E4X8
Ensembl - ENSMUSG00000039156
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stim2aENSDARG00000074867Danio rerio
 stim2bENSDARG00000001776Danio rerio
 STIM2ENSGALG00000014355Gallus gallus
 STIM2ENSG00000109689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stim1 / P70302 / Stromal interaction molecule 1 / Q13586*ENSMUSG0000003098742


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032393  Stromal interaction molecule, Orai1-activating region


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002115 store-operated calcium entry IBA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0032237 activation of store-operated calcium channel activity ISO
 biological_processGO:0051928 positive regulation of calcium ion transport ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISA
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015279 store-operated calcium channel activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002221 abnormal lymph organ size "change in the normal size of lymphatic tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mgmttm1Mse/Mgmttm1Mse,Mlh1tm1Mse/Mlh1tm1Mse
Genetic Background: involves: 129S/SvEv

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008407 decreased cellular sensitivity to hydrogen peroxide "reduced incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Stim1tm1Kuro/Stim1tm1Kuro,Stim2tm1.1Kuro/Stim2tm1.1Kuro,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

Allelic Composition: Stim1tm1Rao/Stim1tm1Rao,Stim2tm1Rao/Stim2tm1Rao,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Oca2p-Btlr/Oca2p-Btlr
Genetic Background: C57BL/6J-Oca2p-Btlr

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Stim2tm1Beni/Stim2tm1Beni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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