ENSMUSG00000057378


Mus musculus

Features
Gene ID: ENSMUSG00000057378
  
Biological name :Ryr3
  
Synonyms : A2AGL3 / Ryanodine receptor 3 / Ryr3
  
Possible biological names infered from orthology : Q15413
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E4
Gene start: 112631355
Gene end: 113217096
  
Corresponding Affymetrix probe sets: 10485840 (MoGene1.0st)   1427427_at (Mouse Genome 430 2.0 Array)   1432133_at (Mouse Genome 430 2.0 Array)   1452533_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147196
Ensembl peptide - ENSMUSP00000079503
Ensembl peptide - ENSMUSP00000147250
Ensembl peptide - ENSMUSP00000089426
Ensembl peptide - ENSMUSP00000146719
Ensembl peptide - ENSMUSP00000146449
NCBI entrez gene - 20192     See in Manteia.
MGI - MGI:99684
RefSeq - XM_017316702
RefSeq - XM_017316705
RefSeq - XM_017316711
RefSeq - XM_017316710
RefSeq - XM_017316709
RefSeq - NM_001319156
RefSeq - NM_177652
RefSeq - XM_017316712
RefSeq - XM_017316708
RefSeq - XM_017316700
RefSeq Peptide - NP_808320
RefSeq Peptide - NP_001306085
swissprot - E9PW34
swissprot - A0A140LI87
swissprot - A0A140LJF7
swissprot - A0A140LJK7
swissprot - A2AGL3
Ensembl - ENSMUSG00000057378
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ryr3ENSDARG00000071331Danio rerio
 RYR3ENSGALG00000009705Gallus gallus
 RYR3ENSG00000198838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ryr2 / E9Q401 / ryanodine receptor 2, cardiac / Q92736* / ryanodine receptor 2*ENSMUSG0000002131369
Ryr1 / E9PZQ0 / Ryanodine receptor 1 / P21817*ENSMUSG0000003059267
Itpr3 / P70227 / Inositol 1,4,5-trisphosphate receptor type 3 / Q14573*ENSMUSG0000004264413
Itpr2 / Q9Z329 / Inositol 1,4,5-trisphosphate receptor type 2 / Q14571*ENSMUSG0000003028713
Itpr1 / P11881 / Inositol 1,4,5-trisphosphate receptor type 1 / Q14643*ENSMUSG0000003010213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000699  RIH domain
 IPR001870  B30.2/SPRY domain
 IPR002048  EF-hand domain
 IPR003032  Ryanodine receptor Ryr
 IPR003877  SPRY domain
 IPR005821  Ion transport domain
 IPR009460  Ryanodine Receptor TM 4-6
 IPR011992  EF-hand domain pair
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013333  Ryanodine receptor
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016024  Armadillo-type fold
 IPR016093  MIR motif
 IPR035761  Ryanodine receptor, SPRY domain 1
 IPR035762  Ryanodine receptor, SPRY domain 3
 IPR035764  Ryanodine receptor, SPRY domain 2
 IPR035910  RyR/IP3 receptor binding core, RIH domain superfamily
 IPR036300  Mir domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006941 striated muscle contraction IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization ISS
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0071286 cellular response to magnesium ion ISS
 biological_processGO:0071313 cellular response to caffeine ISS
 biological_processGO:0071318 cellular response to ATP ISS
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030314 junctional membrane complex IDA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005219 ryanodine-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015278 calcium-release channel activity ISO
 molecular_functionGO:0048763 calcium-induced calcium release activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000738 impaired muscle contractility "inability or reduced ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurog2tm2Fgu/Neurog2tm2Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Ryr3tm1Vso/Ryr3tm1Vso
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ryr3tm2Tno/Ryr3tm2Tno
Genetic Background: involves: 129S4/SvJae

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cbstm1Unc/Cbs+
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

Allelic Composition: Ryr3tm1Jms/Ryr3tm1Jms
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cbstm1Unc/Cbs+
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr3tm1Jms/Ryr3tm1Jms
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Ryr3tm1Jms/Ryr3tm1Jms
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cbstm1Unc/Cbs+
Genetic Background: B6.129P2-Cbstm1Unc/J

Allelic Composition: Ryr3tm1Tno/Ryr3+
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Neurog2tm2Fgu/Neurog2tm2Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Allelic Composition: Ryr3tm1Vso/Ryr3tm1Vso
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000057378 Ryr3 / A2AGL3 / Ryanodine receptor 3 / Q15413*  / complex






 

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