ENSG00000198838


Homo sapiens

Features
Gene ID: ENSG00000198838
  
Biological name :RYR3
  
Synonyms : Q15413 / ryanodine receptor 3 / RYR3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q13.3
Gene start: 33310945
Gene end: 33866121
  
Corresponding Affymetrix probe sets: 206306_at (Human Genome U133 Plus 2.0 Array)   241901_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399610
Ensembl peptide - ENSP00000373884
Ensembl peptide - ENSP00000483166
Ensembl peptide - ENSP00000490632
Ensembl peptide - ENSP00000490438
Ensembl peptide - ENSP00000490033
Ensembl peptide - ENSP00000489937
Ensembl peptide - ENSP00000489832
Ensembl peptide - ENSP00000489672
Ensembl peptide - ENSP00000489529
Ensembl peptide - ENSP00000489346
Ensembl peptide - ENSP00000489294
Ensembl peptide - ENSP00000489262
NCBI entrez gene - 6263     See in Manteia.
OMIM - 180903
RefSeq - XM_017022477
RefSeq - NM_001036
RefSeq - NM_001243996
RefSeq - XM_011521880
RefSeq - XM_017022468
RefSeq - XM_017022469
RefSeq - XM_017022470
RefSeq - XM_017022471
RefSeq - XM_017022472
RefSeq - XM_017022473
RefSeq - XM_017022474
RefSeq - XM_017022475
RefSeq - XM_017022476
RefSeq Peptide - NP_001027
RefSeq Peptide - NP_001230925
swissprot - A0A1B0GVS2
swissprot - A0A1B0GVA9
swissprot - A0A1B0GUB0
swissprot - A0A1B0GU27
swissprot - A0A1B0GTT7
swissprot - A0A1B0GTF2
swissprot - A0A0X1KG73
swissprot - A0A0U1RRH1
swissprot - A0A0U1RR54
swissprot - A0A0U1RR21
swissprot - Q15413
swissprot - A0A087X080
Ensembl - ENSG00000198838
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ryr3ENSDARG00000071331Danio rerio
 RYR3ENSGALG00000009705Gallus gallus
 Ryr3ENSMUSG00000057378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RYR2 / Q92736 / ryanodine receptor 2ENSG0000019862670
RYR1 / P21817 / ryanodine receptor 1ENSG0000019621867
ITPR1 / Q14643 / inositol 1,4,5-trisphosphate receptor type 1ENSG0000015099513
ITPR3 / Q14573 / inositol 1,4,5-trisphosphate receptor type 3ENSG0000009643313
ITPR2 / Q14571 / inositol 1,4,5-trisphosphate receptor type 2ENSG0000012310413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000699  RIH domain
 IPR001870  B30.2/SPRY domain
 IPR002048  EF-hand domain
 IPR003032  Ryanodine receptor Ryr
 IPR003877  SPRY domain
 IPR005821  Ion transport domain
 IPR009460  Ryanodine Receptor TM 4-6
 IPR011992  EF-hand domain pair
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013333  Ryanodine receptor
 IPR013662  RyR/IP3R Homology associated domain
 IPR014821  Inositol 1,4,5-trisphosphate/ryanodine receptor
 IPR015925  Ryanodine receptor-related
 IPR016024  Armadillo-type fold
 IPR016093  MIR motif
 IPR035761  Ryanodine receptor, SPRY domain 1
 IPR035762  Ryanodine receptor, SPRY domain 3
 IPR035764  Ryanodine receptor, SPRY domain 2
 IPR035910  RyR/IP3 receptor binding core, RIH domain superfamily
 IPR036300  Mir domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization ISS
 biological_processGO:0051481 negative regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0071286 cellular response to magnesium ion ISS
 biological_processGO:0071313 cellular response to caffeine ISS
 biological_processGO:0071318 cellular response to ATP ISS
 biological_processGO:1903779 regulation of cardiac conduction TAS
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum ISS
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005219 ryanodine-sensitive calcium-release channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0015278 calcium-release channel activity IMP
 molecular_functionGO:0048763 calcium-induced calcium release activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198838 RYR3 / Q15413 / ryanodine receptor 3  / complex






 

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