ENSG00000168743


Homo sapiens

Features
Gene ID: ENSG00000168743
  
Biological name :NPNT
  
Synonyms : nephronectin / NPNT / Q6UXI9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q24
Gene start: 105894775
Gene end: 106004027
  
Corresponding Affymetrix probe sets: 225911_at (Human Genome U133 Plus 2.0 Array)   244747_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426219
Ensembl peptide - ENSP00000426146
Ensembl peptide - ENSP00000426951
Ensembl peptide - ENSP00000427507
Ensembl peptide - ENSP00000302557
Ensembl peptide - ENSP00000369323
Ensembl peptide - ENSP00000389252
Ensembl peptide - ENSP00000402884
Ensembl peptide - ENSP00000421480
Ensembl peptide - ENSP00000422044
Ensembl peptide - ENSP00000422474
NCBI entrez gene - 255743     See in Manteia.
OMIM - 610306
RefSeq - XM_017007984
RefSeq - NM_001184690
RefSeq - NM_001184691
RefSeq - NM_001184692
RefSeq - NM_001184693
RefSeq - XM_005262888
RefSeq - XM_005262890
RefSeq - XM_011531820
RefSeq - XM_011531822
RefSeq - XM_011531823
RefSeq - XM_011531824
RefSeq - XM_011531825
RefSeq - NM_001033047
RefSeq Peptide - NP_001171619
RefSeq Peptide - NP_001171620
RefSeq Peptide - NP_001171621
RefSeq Peptide - NP_001171622
RefSeq Peptide - NP_001028219
swissprot - D6RE63
swissprot - D6RH31
swissprot - H0Y8M1
swissprot - H0YA60
swissprot - H0YAK9
swissprot - Q6UXI9
Ensembl - ENSG00000168743
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nephronectinENSDARG00000100797Danio rerio
 npntENSDARG00000018721Danio rerio
 NPNTENSGALG00000043555Gallus gallus
 NpntENSMUSG00000040998Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGFL6 / Q8IUX8 / EGF like domain multiple 6ENSG0000019875936
EGFL7 / Q9UHF1 / EGF like domain multiple 7ENSG0000017288913
EGFL8 / Q99944 / EGF like domain multiple 8ENSG0000024140410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000998  MAM domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development ISS
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization ISS
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0033631 cell-cell adhesion mediated by integrin ISS
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation ISS
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0097195 pilomotor reflex IEA
 biological_processGO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030485 smooth muscle contractile fiber IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0034678 integrin alpha8-beta1 complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005178 integrin binding NAS
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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