ENSMUSG00000040998


Mus musculus

Features
Gene ID: ENSMUSG00000040998
  
Biological name :Npnt
  
Synonyms : Nephronectin / Npnt / Q91V88
  
Possible biological names infered from orthology : Q6UXI9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 132881745
Gene end: 132950291
  
Corresponding Affymetrix probe sets: 10502240 (MoGene1.0st)   1421429_a_at (Mouse Genome 430 2.0 Array)   1426560_a_at (Mouse Genome 430 2.0 Array)   1426561_a_at (Mouse Genome 430 2.0 Array)   1452106_at (Mouse Genome 430 2.0 Array)   1452107_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113419
Ensembl peptide - ENSMUSP00000112816
Ensembl peptide - ENSMUSP00000113752
Ensembl peptide - ENSMUSP00000040071
Ensembl peptide - ENSMUSP00000040684
Ensembl peptide - ENSMUSP00000091505
NCBI entrez gene - 114249     See in Manteia.
MGI - MGI:2148811
RefSeq - XM_006500915
RefSeq - NM_001029836
RefSeq - NM_001287101
RefSeq - NM_001287102
RefSeq - NM_001287103
RefSeq - NM_033525
RefSeq Peptide - NP_001274032
RefSeq Peptide - NP_277060
RefSeq Peptide - NP_001274030
RefSeq Peptide - NP_001025007
RefSeq Peptide - NP_001274031
swissprot - Q91V88
swissprot - D3Z4D3
swissprot - D3YTX1
Ensembl - ENSMUSG00000040998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nephronectinENSDARG00000100797Danio rerio
 npntENSDARG00000018721Danio rerio
 NPNTENSGALG00000043555Gallus gallus
 NPNTENSG00000168743Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egfl6 / Q9JJZ5 / Epidermal growth factor-like protein 6 / Q8IUX8* / EGF like domain multiple 6*ENSMUSG0000000040235
Egfl7 / EGF like domain multiple 7 / Q9UHF1*ENSMUSG0000002692112
Egfl8 / Q6GUQ1 / Epidermal growth factor-like protein 8 / Q99944* / EGF like domain multiple 8*ENSMUSG000000154679


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000998  MAM domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IPI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010694 positive regulation of alkaline phosphatase activity IDA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IDA
 biological_processGO:0045184 establishment of protein localization IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045987 positive regulation of smooth muscle contraction IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0097195 pilomotor reflex IMP
 biological_processGO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030485 smooth muscle contractile fiber IDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0034678 integrin alpha8-beta1 complex IDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

 MP:0003604 single kidney 
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sall4tm1Bili/Sall4+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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