ENSMUSG00000026921


Mus musculus

Features
Gene ID: ENSMUSG00000026921
  
Biological name :Egfl7
  
Synonyms : Egfl7 / EGF like domain multiple 7
  
Possible biological names infered from orthology : Q9UHF1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 26580014
Gene end: 26593120
  
Corresponding Affymetrix probe sets: 10470283 (MoGene1.0st)   10470296 (MoGene1.0st)   1421335_a_at (Mouse Genome 430 2.0 Array)   1435823_x_at (Mouse Genome 430 2.0 Array)   1451427_a_at (Mouse Genome 430 2.0 Array)   1451428_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123465
Ensembl peptide - ENSMUSP00000133968
Ensembl peptide - ENSMUSP00000134034
Ensembl peptide - ENSMUSP00000134186
Ensembl peptide - ENSMUSP00000134503
Ensembl peptide - ENSMUSP00000097863
Ensembl peptide - ENSMUSP00000099971
Ensembl peptide - ENSMUSP00000115482
Ensembl peptide - ENSMUSP00000118924
Ensembl peptide - ENSMUSP00000121896
Ensembl peptide - ENSMUSP00000122245
Ensembl peptide - ENSMUSP00000128741
Ensembl peptide - ENSMUSP00000133465
NCBI entrez gene - 353156     See in Manteia.
MGI - MGI:2449923
RefSeq - NM_198724
RefSeq - NM_198725
RefSeq - NM_001164564
RefSeq - NM_178444
RefSeq Peptide - NP_942017
RefSeq Peptide - NP_942018
RefSeq Peptide - NP_848538
RefSeq Peptide - NP_001158036
swissprot - Q3UTJ7
swissprot - A0A0R4J189
swissprot - E9Q4M7
swissprot - F6RMR6
swissprot - F6W8P4
swissprot - F7BU34
swissprot - G3UWX8
swissprot - G3UY71
swissprot - G3UYR2
swissprot - G3UZH9
Ensembl - ENSMUSG00000026921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egfl7ENSDARG00000100657Danio rerio
 si:ch211-194g2.4ENSDARG00000094648Danio rerio
 EGFL7ENSGALG00000043499Gallus gallus
 EGFL7ENSG00000172889Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egfl8 / Q6GUQ1 / Epidermal growth factor-like protein 8 / Q99944* / EGF like domain multiple 8*ENSMUSG0000001546734
Npnt / Q91V88 / Nephronectin / Q6UXI9*ENSMUSG0000004099826
Egfl6 / Q9JJZ5 / Epidermal growth factor-like protein 6 / Q8IUX8* / EGF like domain multiple 6*ENSMUSG0000000040224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR011489  EMI domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd2tm2Som/Pkd2+,Pkhd1tm1Gwu/Pkhd1tm1Gwu
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Egfl7Gt(1-13)Stmn/Egfl7Gt(1-13)Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: E2f2tm1Zubi/E2f2tm1Zubi,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * DBA/2J

Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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