ENSG00000170962


Homo sapiens

Features
Gene ID: ENSG00000170962
  
Biological name :PDGFD
  
Synonyms : PDGFD / platelet derived growth factor D / Q9GZP0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q22.3
Gene start: 103907186
Gene end: 104164379
  
Corresponding Affymetrix probe sets: 219304_s_at (Human Genome U133 Plus 2.0 Array)   222860_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000376865
Ensembl peptide - ENSP00000302193
Ensembl peptide - ENSP00000432909
NCBI entrez gene - 80310     See in Manteia.
OMIM - 609673
RefSeq - NM_033135
RefSeq - NM_025208
RefSeq Peptide - NP_079484
RefSeq Peptide - NP_149126
swissprot - Q9GZP0
swissprot - H0YD37
Ensembl - ENSG00000170962
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdgfdENSDARG00000077677Danio rerio
 PDGFDENSGALG00000017179Gallus gallus
 PdgfdENSMUSG00000032006Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDGFC / Q9NRA1 / platelet derived growth factor CENSG0000014543140


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR000859  CUB domain
 IPR027123  Platelet-derived growth factor D
 IPR029034  Cystine-knot cytokine
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007596 blood coagulation IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0030335 positive regulation of cell migration IBA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IBA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IBA
 biological_processGO:0048008 platelet-derived growth factor receptor signaling pathway IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0071673 positive regulation of smooth muscle cell chemotaxis IEA
 biological_processGO:0072126 positive regulation of glomerular mesangial cell proliferation IEA
 biological_processGO:2000439 positive regulation of monocyte extravasation IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005161 platelet-derived growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104368 PLAT / P00750 / plasminogen activator, tissue type  / reaction
 ENSG00000122194 PLG / P00747 / plasminogen  / reaction
 ENSG00000170962 PDGFD / Q9GZP0 / platelet derived growth factor D  / complex






 

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