ENSG00000171444


Homo sapiens

Features
Gene ID: ENSG00000171444
  
Biological name :MCC
  
Synonyms : MCC / mutated in colorectal cancers / P23508
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q22.2
Gene start: 113022099
Gene end: 113488830
  
Corresponding Affymetrix probe sets: 206132_at (Human Genome U133 Plus 2.0 Array)   226225_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386227
Ensembl peptide - ENSP00000485492
Ensembl peptide - ENSP00000485220
Ensembl peptide - ENSP00000421615
Ensembl peptide - ENSP00000305617
NCBI entrez gene - 4163     See in Manteia.
OMIM - 159350
RefSeq - XM_005271991
RefSeq - XM_017009474
RefSeq - XM_017009473
RefSeq - NM_001085377
RefSeq - NM_002387
RefSeq Peptide - NP_001078846
RefSeq Peptide - NP_002378
swissprot - P23508
swissprot - D6REY2
swissprot - A0A096LNU0
swissprot - A0A096LPB3
Ensembl - ENSG00000171444
  
Related genetic diseases (OMIM): 114500 - Colorectal cancer, somatic, 114500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mccENSDARG00000105237Danio rerio
 MCCENSGALG00000000208Gallus gallus
 MccENSMUSG00000071856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8N6Y0 / USHBP1 / USH1 protein network component harmonin binding protein 1ENSG0000013030716


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site
 IPR019536  Usher syndrome type-1C protein-binding protein 1, PDZ domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010633 negative regulation of epithelial cell migration IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0045184 establishment of protein localization IDA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IDA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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