ENSG00000172009


Homo sapiens

Features
Gene ID: ENSG00000172009
  
Biological name :THOP1
  
Synonyms : P52888 / thimet oligopeptidase 1 / THOP1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 2785460
Gene end: 2815807
  
Corresponding Affymetrix probe sets: 203235_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467226
Ensembl peptide - ENSP00000465895
Ensembl peptide - ENSP00000466653
Ensembl peptide - ENSP00000304467
Ensembl peptide - ENSP00000378638
Ensembl peptide - ENSP00000464786
Ensembl peptide - ENSP00000465545
Ensembl peptide - ENSP00000465855
NCBI entrez gene - 7064     See in Manteia.
OMIM - 601117
RefSeq - XM_011528228
RefSeq - NM_003249
RefSeq Peptide - NP_003240
swissprot - K7EL32
swissprot - K7EMU4
swissprot - K7EP46
swissprot - K7EIK4
swissprot - P52888
swissprot - K7EL02
swissprot - K7EKB6
Ensembl - ENSG00000172009
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 thop1ENSDARG00000013776Danio rerio
 THOP1ENSGALG00000041934Gallus gallus
 Thop1ENSMUSG00000004929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLN / Q9BYT8 / neurolysinENSG0000012321362


Protein motifs (from Interpro)
Interpro ID Name
 IPR001567  Peptidase M3A/M3B catalytic domain
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR024080  Neurolysin/Thimet oligopeptidase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006518 peptide metabolic process IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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