ENSG00000172057


Homo sapiens

Features
Gene ID: ENSG00000172057
  
Biological name :ORMDL3
  
Synonyms : ORMDL3 / ORMDL sphingolipid biosynthesis regulator 3 / Q8N138
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q21.1
Gene start: 39921041
Gene end: 39927601
  
Corresponding Affymetrix probe sets: 223259_at (Human Genome U133 Plus 2.0 Array)   235136_at (Human Genome U133 Plus 2.0 Array)   240701_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464455
Ensembl peptide - ENSP00000464298
Ensembl peptide - ENSP00000464693
Ensembl peptide - ENSP00000304858
Ensembl peptide - ENSP00000377724
Ensembl peptide - ENSP00000462961
NCBI entrez gene - 94103     See in Manteia.
OMIM - 610075
RefSeq - XM_017025348
RefSeq - NM_001320801
RefSeq - NM_001320802
RefSeq - NM_001320803
RefSeq - NM_139280
RefSeq - XM_017025345
RefSeq - XM_017025346
RefSeq - XM_017025347
RefSeq Peptide - NP_001307730
RefSeq Peptide - NP_001307732
RefSeq Peptide - NP_644809
RefSeq Peptide - NP_001307731
swissprot - A0A024R1W6
swissprot - J3KTF9
swissprot - J3QRM9
swissprot - Q8N138
Ensembl - ENSG00000172057
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ormdl3ENSDARG00000025555Danio rerio
 ORMDL3ENSGALG00000029142Gallus gallus
 Ormdl3ENSMUSG00000038150Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ORMDL1 / Q9P0S3 / ORMDL sphingolipid biosynthesis regulator 1ENSG0000012869984
ORMDL2 / Q53FV1 / ORMDL sphingolipid biosynthesis regulator 2ENSG0000012335380


Protein motifs (from Interpro)
Interpro ID Name
 IPR007203  ORMDL family
 IPR029883  ORM1-like protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0090156 cellular sphingolipid homeostasis IEA
 biological_processGO:1900060 negative regulation of ceramide biosynthetic process IMP
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0035339 SPOTS complex IDA
 cellular_componentGO:0035579 specific granule membrane TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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