ENSG00000172296


Homo sapiens

Features
Gene ID: ENSG00000172296
  
Biological name :SPTLC3
  
Synonyms : Q9NUV7 / serine palmitoyltransferase long chain base subunit 3 / SPTLC3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: p12.1
Gene start: 13008979
Gene end: 13169103
  
Corresponding Affymetrix probe sets: 220456_at (Human Genome U133 Plus 2.0 Array)   227752_at (Human Genome U133 Plus 2.0 Array)   236201_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409125
Ensembl peptide - ENSP00000409760
Ensembl peptide - ENSP00000381968
Ensembl peptide - ENSP00000389749
NCBI entrez gene - 55304     See in Manteia.
OMIM - 611120
RefSeq - XM_017027922
RefSeq - NM_018327
RefSeq - XM_011529279
RefSeq - XM_011529280
RefSeq Peptide - NP_001336874
RefSeq Peptide - NP_060797
swissprot - Q9NUV7
swissprot - B1AKS3
swissprot - H0Y733
swissprot - B1AKS2
Ensembl - ENSG00000172296
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sptlc3ENSDARG00000030743Danio rerio
 SPTLC3ENSGALG00000009037Gallus gallus
 Q8BG54ENSMUSG00000039092Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15270 / SPTLC2 / serine palmitoyltransferase long chain base subunit 2ENSG0000010059669


Protein motifs (from Interpro)
Interpro ID Name
 IPR001917  Aminotransferase, class-II, pyridoxal-phosphate binding site
 IPR004839  Aminotransferase, class I/classII
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006665 sphingolipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0046520 sphingoid biosynthetic process IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017059 serine C-palmitoyltransferase complex IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004758 serine C-palmitoyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090054 O15269 / SPTLC1 / serine palmitoyltransferase long chain base subunit 1  / complex
 ENSG00000196542 Q8NFR3 / SPTSSB / serine palmitoyltransferase small subunit B  / complex
 ENSG00000165389 Q969W0 / SPTSSA / serine palmitoyltransferase small subunit A  / complex






 

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