ENSG00000173083


Homo sapiens

Features
Gene ID: ENSG00000173083
  
Biological name :HPSE
  
Synonyms : heparanase / HPSE / Q9Y251
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.23
Gene start: 83292461
Gene end: 83335153
  
Corresponding Affymetrix probe sets: 219403_s_at (Human Genome U133 Plus 2.0 Array)   222881_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421365
Ensembl peptide - ENSP00000426139
Ensembl peptide - ENSP00000423265
Ensembl peptide - ENSP00000421827
Ensembl peptide - ENSP00000308107
Ensembl peptide - ENSP00000384262
Ensembl peptide - ENSP00000421038
NCBI entrez gene - 10855     See in Manteia.
OMIM - 604724
RefSeq - NM_001199830
RefSeq - NM_006665
RefSeq - NM_001098540
RefSeq - NM_001166498
RefSeq Peptide - NP_001159970
RefSeq Peptide - NP_006656
RefSeq Peptide - NP_001092010
RefSeq Peptide - NP_001186759
swissprot - Q9Y251
swissprot - D6RAQ1
swissprot - D6RHG4
Ensembl - ENSG00000173083
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpseENSDARG00000063634Danio rerio
 HPSEENSGALG00000011203Gallus gallus
 HpseENSMUSG00000035273Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HPSE2 / Q8WWQ2 / heparanase 2 (inactive)ENSG0000017298744


Protein motifs (from Interpro)
Interpro ID Name
 IPR005199  Glycoside hydrolase, family 79
 IPR017853  Glycoside hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006027 glycosaminoglycan catabolic process TAS
 biological_processGO:0006029 proteoglycan metabolic process TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IDA
 biological_processGO:0030194 positive regulation of blood coagulation IDA
 biological_processGO:0030200 heparan sulfate proteoglycan catabolic process IDA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IDA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0051797 regulation of hair follicle development IDA
 biological_processGO:0051798 positive regulation of hair follicle development IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060055 angiogenesis involved in wound healing IBA
 biological_processGO:0061042 vascular wound healing IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0043202 lysosomal lumen TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004566 beta-glucuronidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030305 heparanase activity TAS
 molecular_functionGO:0045545 syndecan binding IDA
 molecular_functionGO:0046983 protein dimerization activity IDA


Pathways (from Reactome)
Pathway description
HS-GAG degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173083 HPSE / Q9Y251 / heparanase  / complex






 

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