ENSMUSG00000035273


Mus musculus

Features
Gene ID: ENSMUSG00000035273
  
Biological name :Hpse
  
Synonyms : Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit / Hpse / Q6YGZ1
  
Possible biological names infered from orthology : heparanase / Q9Y251
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 100679484
Gene end: 100719716
  
Corresponding Affymetrix probe sets: 10531737 (MoGene1.0st)   1433930_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108529
Ensembl peptide - ENSMUSP00000044072
NCBI entrez gene - 15442     See in Manteia.
MGI - MGI:1343124
RefSeq - NM_152803
RefSeq Peptide - NP_690016
swissprot - D3Z3C3
swissprot - Q6YGZ1
Ensembl - ENSMUSG00000035273
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hpseENSDARG00000063634Danio rerio
 HPSEENSGALG00000011203Gallus gallus
 HPSEENSG00000173083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hpse2 / B2RY83 / Inactive heparanase-2 / Q8WWQ2* / heparanase 2 (inactive)*ENSMUSG0000007485245


Protein motifs (from Interpro)
Interpro ID Name
 IPR005199  Glycoside hydrolase, family 79
 IPR017853  Glycoside hydrolase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030200 heparan sulfate proteoglycan catabolic process IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0042060 wound healing IDA
 biological_processGO:0051797 regulation of hair follicle development IEA
 biological_processGO:0051798 positive regulation of hair follicle development IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IDA
 biological_processGO:0061042 vascular wound healing IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030305 heparanase activity IEA
 molecular_functionGO:0045545 syndecan binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
HS-GAG degradation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0008117 abnormal Langerhans cell morphology "any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035273 Hpse / Q6YGZ1 / Heparanase Heparanase 8 kDa subunit Heparanase 50 kDa subunit / Q9Y251* / heparanase*  / complex






 

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