ENSG00000173432


Homo sapiens

Features
Gene ID: ENSG00000173432
  
Biological name :SAA1
  
Synonyms : P0DJI8 / SAA1 / serum amyloid A1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.1
Gene start: 18266174
Gene end: 18269977
  
Corresponding Affymetrix probe sets: 208607_s_at (Human Genome U133 Plus 2.0 Array)   214456_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436866
Ensembl peptide - ENSP00000348918
Ensembl peptide - ENSP00000384906
NCBI entrez gene - 6288     See in Manteia.
OMIM - 104750
RefSeq - NM_000331
RefSeq - NM_001178006
RefSeq - NM_199161
RefSeq Peptide - NP_000322
RefSeq Peptide - NP_001171477
RefSeq Peptide - NP_954630
swissprot - P0DJI8
swissprot - E9PQD6
Ensembl - ENSG00000173432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 saaENSDARG00000045999Danio rerio
 ENSGALG00000027716Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SAA2 / P0DJI9 / serum amyloid A2ENSG0000013433993
SAA2-SAA4 / SAA2-SAA4 readthroughENSG0000025507179
SAA4 / P35542 / serum amyloid A4, constitutiveENSG0000014896555


Protein motifs (from Interpro)
Interpro ID Name
 IPR000096  Serum amyloid A protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006953 acute-phase response NAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030168 platelet activation NAS
 biological_processGO:0030593 neutrophil chemotaxis NAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045785 positive regulation of cell adhesion NAS
 biological_processGO:0048246 macrophage chemotaxis IDA
 biological_processGO:0048247 lymphocyte chemotaxis IDA
 biological_processGO:0050708 regulation of protein secretion NAS
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050716 positive regulation of interleukin-1 secretion NAS
 biological_processGO:0050728 negative regulation of inflammatory response NAS
 biological_processGO:0050918 positive chemotaxis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005881 cytoplasmic microtubule IDA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042056 chemoattractant activity IBA


Pathways (from Reactome)
Pathway description
Scavenging by Class B Receptors
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Interleukin-4 and Interleukin-13 signaling
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000093 Proteinuria 
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 HP:0000100 Nephrotic syndrome 
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 HP:0000105 Enlarged kidneys 
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 HP:0000112 Nephropathy "A nonspecific term referring to disease or damage of the kidneys." [HPO:curators]
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 HP:0000821 Hypothyroidism 
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 HP:0000846 Adrenal insufficiency 
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 HP:0001396 Cholestasis 
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 HP:0001627 Cardiac abnormality "An abnormality of the `heart` (FMA:7088)." [HPO:probinson]
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 HP:0001917 Renal amyloidosis 
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 HP:0001919 Acute renal failure 
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 HP:0002013 Vomiting 
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 HP:0002018 Nausea 
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 HP:0002024 Malabsorption 
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 HP:0002027 Abdominal pain 
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 HP:0002028 Chronic diarrhea 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002615 Hypotension 
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 HP:0004395 Malnutrition 
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 HP:0004936 Venous thrombosis 
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 HP:0011830 Abnormality of oral mucosa "Abnormality of the `oral mucosa` (FMA:59660)." [HPO:probinson]
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 HP:0012622 Chronic kidney disease "Functional anomaly of the kidney persisting for at least three months." [Eurenomics:ewuehl]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173432 SAA1 / P0DJI8 / serum amyloid A1  / -






 

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