ENSG00000174672


Homo sapiens

Features
Gene ID: ENSG00000174672
  
Biological name :BRSK2
  
Synonyms : BR serine/threonine kinase 2 / BRSK2 / Q8IWQ3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 1389899
Gene end: 1462689
  
Corresponding Affymetrix probe sets: 215010_s_at (Human Genome U133 Plus 2.0 Array)   223715_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433235
Ensembl peptide - ENSP00000432672
Ensembl peptide - ENSP00000433370
Ensembl peptide - ENSP00000445168
Ensembl peptide - ENSP00000436474
Ensembl peptide - ENSP00000434075
Ensembl peptide - ENSP00000433684
Ensembl peptide - ENSP00000310697
Ensembl peptide - ENSP00000371614
Ensembl peptide - ENSP00000431152
Ensembl peptide - ENSP00000432000
Ensembl peptide - ENSP00000432252
NCBI entrez gene - 9024     See in Manteia.
OMIM - 609236
RefSeq - XM_017018538
RefSeq - NM_001282218
RefSeq - NM_003957
RefSeq - XM_005253218
RefSeq - XM_006718374
RefSeq - XM_006718376
RefSeq - XM_011520461
RefSeq - XM_011520462
RefSeq - XM_017018532
RefSeq - XM_017018533
RefSeq - XM_017018534
RefSeq - XM_017018535
RefSeq - XM_017018536
RefSeq - XM_017018537
RefSeq - NM_001256627
RefSeq - NM_001256629
RefSeq - NM_001256630
RefSeq Peptide - NP_001243558
RefSeq Peptide - NP_001243559
RefSeq Peptide - NP_001269147
RefSeq Peptide - NP_003948
RefSeq Peptide - NP_001243556
swissprot - H0YES6
swissprot - Q8IWQ3
swissprot - A0A024RCE9
swissprot - E9PRY3
swissprot - E9PPI2
swissprot - A0A140VJF6
swissprot - A0A0C4DGH9
swissprot - H0YCS6
Ensembl - ENSG00000174672
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brsk2bENSDARG00000077791Danio rerio
 FQ311928.1ENSDARG00000061421Danio rerio
 BRSK2ENSGALG00000006681Gallus gallus
 Brsk2ENSMUSG00000053046Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BRSK1 / Q8TDC3 / BR serine/threonine kinase 1ENSG0000016046969


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0036503 ERAD pathway IMP
 biological_processGO:0043462 regulation of ATPase activity NAS
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 biological_processGO:1904152 regulation of retrograde protein transport, ER to cytosol NAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity ISS
 molecular_functionGO:0051117 ATPase binding IDA
 molecular_functionGO:0060590 ATPase regulator activity NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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