ENSMUSG00000053046


Mus musculus

Features
Gene ID: ENSMUSG00000053046
  
Biological name :Brsk2
  
Synonyms : Brsk2 / Q69Z98 / Serine/threonine-protein kinase BRSK2
  
Possible biological names infered from orthology : BR serine/threonine kinase 2 / Q8IWQ3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 141949751
Gene end: 142004247
  
Corresponding Affymetrix probe sets: 10559146 (MoGene1.0st)   1431826_a_at (Mouse Genome 430 2.0 Array)   1439329_a_at (Mouse Genome 430 2.0 Array)   1459639_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134153
Ensembl peptide - ENSMUSP00000134310
Ensembl peptide - ENSMUSP00000134566
Ensembl peptide - ENSMUSP00000018971
Ensembl peptide - ENSMUSP00000074969
Ensembl peptide - ENSMUSP00000077330
Ensembl peptide - ENSMUSP00000101610
Ensembl peptide - ENSMUSP00000133296
Ensembl peptide - ENSMUSP00000133438
Ensembl peptide - ENSMUSP00000133750
Ensembl peptide - ENSMUSP00000133868
Ensembl peptide - ENSMUSP00000134170
Ensembl peptide - ENSMUSP00000134201
Ensembl peptide - ENSMUSP00000134289
NCBI entrez gene - 75770     See in Manteia.
MGI - MGI:1923020
RefSeq - NM_001276763
RefSeq - NM_029426
RefSeq - NM_001009929
RefSeq - NM_001009930
RefSeq Peptide - NP_001263692
RefSeq Peptide - NP_083702
RefSeq Peptide - NP_001009930
RefSeq Peptide - NP_001009929
swissprot - Q69Z98
swissprot - G3UWV4
swissprot - G3UXM5
swissprot - G3UXY1
swissprot - G3UYN4
swissprot - G3UYP7
swissprot - G3UZ00
swissprot - G3UZ19
swissprot - G3UZN4
swissprot - G5E921
Ensembl - ENSMUSG00000053046
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 brsk2bENSDARG00000077791Danio rerio
 FQ311928.1ENSDARG00000061421Danio rerio
 BRSK2ENSGALG00000006681Gallus gallus
 BRSK2ENSG00000174672Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brsk1 / Q5RJI5 / Serine/threonine-protein kinase BRSK1 / Q8TDC3* / BR serine/threonine kinase 1*ENSMUSG0000003539075


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISO
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0030182 neuron differentiation IGI
 biological_processGO:0031532 actin cytoskeleton reorganization ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0036503 ERAD pathway ISO
 biological_processGO:0048812 neuron projection morphogenesis IGI
 biological_processGO:0051301 cell division IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus ISO
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005813 centrosome IBA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity ISO
 molecular_functionGO:0051117 ATPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Brsk2tm2.1Jrs/Brsk2tm2.1Jrs,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Fat1tm1.2Fhel/Fat1tm1.2Fhel,Tg(Myl1-lacZ)1Ibdml/0
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

Allelic Composition: Brsk2tm2.1Jrs/Brsk2tm2.1Jrs,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brsk2tm2.1Jrs/Brsk2tm2.1Jrs,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0008442 disorganized cortical plate "derangement of the patterned arrangement of the cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Brsk2tm2.1Jrs/Brsk2tm2.1Jrs,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Brsk2tm2.1Jrs/Brsk2tm2.1Jrs,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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