ENSMUSG00000035390


Mus musculus

Features
Gene ID: ENSMUSG00000035390
  
Biological name :Brsk1
  
Synonyms : Brsk1 / Q5RJI5 / Serine/threonine-protein kinase BRSK1
  
Possible biological names infered from orthology : BR serine/threonine kinase 1 / Q8TDC3
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 4690604
Gene end: 4715997
  
Corresponding Affymetrix probe sets: 10549679 (MoGene1.0st)   1439892_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145845
Ensembl peptide - ENSMUSP00000145970
Ensembl peptide - ENSMUSP00000039517
Ensembl peptide - ENSMUSP00000113448
Ensembl peptide - ENSMUSP00000145821
NCBI entrez gene - 381979     See in Manteia.
MGI - MGI:2685946
RefSeq - XM_017322325
RefSeq - XM_017322326
RefSeq - NM_001003920
RefSeq - NM_001168572
RefSeq Peptide - NP_001003920
RefSeq Peptide - NP_001162044
swissprot - Q5RJI5
swissprot - D3Z5P0
swissprot - A0A0U1RP43
Ensembl - ENSMUSG00000035390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BRSK1ENSG00000160469Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Brsk2 / Q69Z98 / Serine/threonine-protein kinase BRSK2 / Q8IWQ3* / BR serine/threonine kinase 2*ENSMUSG0000005304669


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017348  Serine/threonine-protein kinase pim-1/2/3
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISO
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint ISS
 biological_processGO:0007269 neurotransmitter secretion ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0009411 response to UV ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0030182 neuron differentiation IGI
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0048812 neuron projection morphogenesis IGI
 biological_processGO:0051298 centrosome duplication IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0008021 synaptic vesicle ISS
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0043015 gamma-tubulin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050321 tau-protein kinase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0008440 abnormal subplate morphology "any strucutral anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0008442 disorganized cortical plate "derangement of the patterned arrangement of the cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Liftm1Cgre/Liftm1Cgre
Genetic Background: involves: MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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