ENSG00000175193


Homo sapiens

Features
Gene ID: ENSG00000175193
  
Biological name :PARL
  
Synonyms : PARL / presenilin associated rhomboid like / Q9H300
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q27.1
Gene start: 183829271
Gene end: 183884933
  
Corresponding Affymetrix probe sets: 218271_s_at (Human Genome U133 Plus 2.0 Array)   228881_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404421
Ensembl peptide - ENSP00000402689
Ensembl peptide - ENSP00000491109
Ensembl peptide - ENSP00000492596
Ensembl peptide - ENSP00000491186
Ensembl peptide - ENSP00000310676
Ensembl peptide - ENSP00000325421
Ensembl peptide - ENSP00000392926
Ensembl peptide - ENSP00000396691
Ensembl peptide - ENSP00000398043
Ensembl peptide - ENSP00000402137
NCBI entrez gene - 55486     See in Manteia.
OMIM - 607858
RefSeq - XM_017006803
RefSeq - NM_001037639
RefSeq - NM_001324436
RefSeq - NM_001324437
RefSeq - NM_001324438
RefSeq - NM_018622
RefSeq - XM_005247582
RefSeq - XM_017006800
RefSeq - XM_017006801
RefSeq - XM_017006802
RefSeq Peptide - NP_061092
RefSeq Peptide - NP_001032728
RefSeq Peptide - NP_001311365
RefSeq Peptide - NP_001311366
RefSeq Peptide - NP_001311367
swissprot - C9JNP8
swissprot - A0A1W2PS40
swissprot - F8WCQ4
swissprot - H7C045
swissprot - H7C0U0
swissprot - Q9H300
swissprot - A0A1W2PP66
swissprot - H7C122
swissprot - H7C1V6
Ensembl - ENSG00000175193
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO018197.1ENSDARG00000020891Danio rerio
 parlaENSDARG00000039310Danio rerio
 ENSGALG00000002315Gallus gallus
 ParlENSMUSG00000033918Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC131160.1ENSG0000028376592


Protein motifs (from Interpro)
Interpro ID Name
 IPR022764  Peptidase S54, rhomboid domain
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006851 mitochondrial calcium ion transmembrane transport TAS
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0030162 regulation of proteolysis IGI
 biological_processGO:0033619 membrane protein proteolysis TAS
 biological_processGO:1903214 regulation of protein targeting to mitochondrion NAS
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004175 endopeptidase activity IMP
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Processing of SMDT1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165283 Q9UJZ1 / STOML2 / stomatin like 2  / complex
 ENSG00000136758 Q96TA2 / YME1L1 / YME1 like 1 ATPase  / complex






 

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