ENSG00000175221


Homo sapiens

Features
Gene ID: ENSG00000175221
  
Biological name :MED16
  
Synonyms : MED16 / mediator complex subunit 16 / Q9Y2X0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 867630
Gene end: 893218
  
Corresponding Affymetrix probe sets: 221418_s_at (Human Genome U133 Plus 2.0 Array)   221544_s_at (Human Genome U133 Plus 2.0 Array)   221545_x_at (Human Genome U133 Plus 2.0 Array)   221938_x_at (Human Genome U133 Plus 2.0 Array)   43544_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000465827
Ensembl peptide - ENSP00000483533
Ensembl peptide - ENSP00000480766
Ensembl peptide - ENSP00000479411
Ensembl peptide - ENSP00000478286
Ensembl peptide - ENSP00000475725
Ensembl peptide - ENSP00000475528
Ensembl peptide - ENSP00000466868
Ensembl peptide - ENSP00000269814
Ensembl peptide - ENSP00000308528
Ensembl peptide - ENSP00000325612
Ensembl peptide - ENSP00000379153
Ensembl peptide - ENSP00000464810
Ensembl peptide - ENSP00000465762
Ensembl peptide - ENSP00000465823
NCBI entrez gene - 10025     See in Manteia.
OMIM - 604062
RefSeq - NM_005481
RefSeq - XM_017026120
RefSeq - XM_017026121
RefSeq Peptide - NP_005472
swissprot - A0A087WU12
swissprot - K7EKS6
swissprot - B9TX21
swissprot - K7EKX6
swissprot - Q9Y2X0
swissprot - U3KQ43
swissprot - U3KQB4
swissprot - K7EKX2
swissprot - B9TX12
swissprot - B9TX11
swissprot - B9TX03
swissprot - B9TWZ6
Ensembl - ENSG00000175221
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med16ENSDARG00000040779Danio rerio
 MED16ENSGALG00000001978Gallus gallus
 Med16ENSMUSG00000013833Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR021665  Mediator complex, subunit Med16
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II NAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IDA
 biological_processGO:0030521 androgen receptor signaling pathway IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016592 mediator complex IDA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IDA
 molecular_functionGO:0042809 vitamin D receptor binding NAS
 molecular_functionGO:0046966 thyroid hormone receptor binding IDA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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