ENSMUSG00000013833


Mus musculus

Features
Gene ID: ENSMUSG00000013833
  
Biological name :Med16
  
Synonyms : Med16 / mediator complex subunit 16
  
Possible biological names infered from orthology : Q9Y2X0
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 79894708
Gene end: 79908923
  
Corresponding Affymetrix probe sets: 10370665 (MoGene1.0st)   1438416_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101017
Ensembl peptide - ENSMUSP00000129375
Ensembl peptide - ENSMUSP00000129229
Ensembl peptide - ENSMUSP00000128463
Ensembl peptide - ENSMUSP00000126729
NCBI entrez gene - 216154     See in Manteia.
MGI - MGI:2158394
RefSeq - XM_011243402
RefSeq - NM_001163276
RefSeq - NM_198107
RefSeq - XM_006513487
RefSeq - XM_006513488
RefSeq Peptide - NP_932775
RefSeq Peptide - NP_001156748
swissprot - E9PWX0
swissprot - G3UW74
swissprot - E9QAH8
swissprot - E9PZW4
swissprot - E9QP84
Ensembl - ENSMUSG00000013833
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med16ENSDARG00000040779Danio rerio
 MED16ENSGALG00000001978Gallus gallus
 MED16ENSG00000175221Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011041  Soluble quinoprotein glucose/sorbosone dehydrogenase
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR021665  Mediator complex, subunit Med16
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0030521 androgen receptor signaling pathway IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016592 mediator complex IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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