ENSG00000175390


Homo sapiens

Features
Gene ID: ENSG00000175390
  
Biological name :EIF3F
  
Synonyms : EIF3F / eukaryotic translation initiation factor 3 subunit F / O00303
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 7970251
Gene end: 8001862
  
Corresponding Affymetrix probe sets: 200023_s_at (Human Genome U133 Plus 2.0 Array)   200865_at (Human Genome U133 Plus 2.0 Array)   226014_at (Human Genome U133 Plus 2.0 Array)   230479_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432489
Ensembl peptide - ENSP00000491198
Ensembl peptide - ENSP00000434286
Ensembl peptide - ENSP00000310040
Ensembl peptide - ENSP00000431800
NCBI entrez gene - 8665     See in Manteia.
OMIM - 603914
RefSeq - NM_003754
RefSeq Peptide - NP_003745
swissprot - E9PQV8
swissprot - A0A1W2PP79
swissprot - H0YDT6
swissprot - O00303
Ensembl - ENSG00000175390
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif3fENSDARG00000077533Danio rerio
 ENSGALG00000005326Gallus gallus
 Eif3fENSMUSG00000031029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
COPS6 / Q7L5N1 / COP9 signalosome subunit 6ENSG0000016809021
PSMD7 / P51665 / proteasome 26S subunit, non-ATPase 7ENSG0000010303521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000555  JAB1/MPN/MOV34 metalloenzyme domain
 IPR024969  Rpn11/EIF3F, C-terminal
 IPR027531  Eukaryotic translation initiation factor 3 subunit F
 IPR037518  MPN domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0075522 IRES-dependent viral translational initiation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m IBA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0031369 translation initiation factor binding IBA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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