ENSG00000176171


Homo sapiens

Features
Gene ID: ENSG00000176171
  
Biological name :BNIP3
  
Synonyms : BCL2 interacting protein 3 / BNIP3 / Q12983
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.3
Gene start: 131966455
Gene end: 131982013
  
Corresponding Affymetrix probe sets: 201848_s_at (Human Genome U133 Plus 2.0 Array)   201849_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446145
Ensembl peptide - ENSP00000487769
Ensembl peptide - ENSP00000357625
NCBI entrez gene - 664     See in Manteia.
OMIM - 603293
RefSeq - NM_004052
RefSeq Peptide - NP_004043
swissprot - A0A0J9YW18
swissprot - F6RP06
swissprot - Q12983
Ensembl - ENSG00000176171
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bnip3ENSDARG00000099961Danio rerio
 bnip4ENSDARG00000022832Danio rerio
 BNIP3ENSGALG00000010476Gallus gallus
 Bnip3ENSMUSG00000078566Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BNIP3L / O60238 / BCL2 interacting protein 3 likeENSG0000010476545


Protein motifs (from Interpro)
Interpro ID Name
 IPR010548  BNIP3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000422 autophagy of mitochondrion NAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006915 apoptotic process IPI
 biological_processGO:0008219 cell death IEA
 biological_processGO:0008626 granzyme-mediated apoptotic signaling pathway IDA
 biological_processGO:0010508 positive regulation of autophagy TAS
 biological_processGO:0010637 negative regulation of mitochondrial fusion IDA
 biological_processGO:0010659 cardiac muscle cell apoptotic process IEA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010821 regulation of mitochondrion organization IEA
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential IEA
 biological_processGO:0010940 positive regulation of necrotic cell death IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016239 positive regulation of macroautophagy IGI
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0035694 mitochondrial protein catabolic process IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043068 positive regulation of programmed cell death IDA
 biological_processGO:0043243 positive regulation of protein complex disassembly IDA
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IDA
 biological_processGO:0045837 negative regulation of membrane potential IDA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IDA
 biological_processGO:0048102 autophagic cell death IEA
 biological_processGO:0048709 oligodendrocyte differentiation IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051561 positive regulation of mitochondrial calcium ion concentration IEA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0060548 negative regulation of cell death IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071279 cellular response to cobalt ion IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:0090141 positive regulation of mitochondrial fission IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IEA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IDA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 biological_processGO:1903599 positive regulation of autophagy of mitochondrion IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005740 mitochondrial envelope IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum NAS
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031307 integral component of mitochondrial outer membrane IDA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IDA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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